Insitro

Insitro

Senior Director, Project & Portfolio Management

South San Francisco, CA · Director

Sponsorship not specified$264k-$298kDetected 280 days ago
Machine LearningData ScienceLLMsAgentic AIProject ManagementBusiness DevelopmentBioinformaticsResearchLeadershipCommunicationCollaboration

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odds of building a lasting career here

57Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role76
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

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H-1B wage level

the lottery is wage-weighted — each level is one more entry

Level IV · 4×
Level I$85,8001 entry
Level II$114,0462 entries
Level III$142,2723 entries
Level IV$170,5184 entries

This range already reaches Level IV — the maximum four lottery entries.

DOL prevailing wage, 2026-27 wage year · Financial and Investment Analysts (13-2051) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.

Employer immigration record

from this employer's Department of Labor filings

Files H-1B transfers

1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • The unprecedented convergence of multi-modal data, advanced disease modeling, and computational power is revolutionizing drug discovery. insitro is harnessing this moment to redefine how medicines are developed for complex diseases.
  • Our AI/ML-enabled platforms integrate and scale data to rapidly discover novel biological insights to redefine complex diseases and identify new targets and drugs.
  • This role will be hybrid, coming onsite to our South San Francisco headquarters with three days per week in the office.

Responsibilities

  • Reporting into the CSO, you and your staff will partner with project team leaders in developing rightsized project strategies and create successful team environments to foster high performance and rapid advancement.
  • Exposure to the design and implementation of agentic workflows in a pharma or biotech environment
  • Support to attend professional conferences that are meaningful to your career growth and role's responsibilities
  • We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease.
  • These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism.
  • Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners.

Requirements

  • Experience with setting up or leading decision making bodies (governance) and/or portfolio planning and reviews processes with appropriate decision tools
  • Solid understanding of metabolism, neuroscience or ophthalmology disease areas and its competitive environment with the ability to take part in strategic discussions
  • Previous experience in high visibility roles requiring the ability to think strategically and summarize complex information into important concepts for broader communication including executive leaders
  • Self-directed and proactive with ability to exercise good judgment and respond quickly and effectively to changing environments

Nice to have

  • Project Management Certification (PMP or equivalent)
  • Familiarity with Google Suite and Smartsheets strongly preferred
  • Prior use of generative AI tools / LLM technologies in day-to-day work (e.g., ChatGPT, Gemini, Claude)
  • Understanding of high-content human data modalities (e.g., genetics/genomics, histopathological imaging, spatial biology) and data generation technologies
  • "Get Things Done": A self-starter, with a strong bias to action, who can prioritize and advance multiple projects under the resource, information and time constraints of an early stage startup
  • "Engage with Respect": Prioritize a compassionate understanding of the needs and perspectives of insitro teams and leaders in every interaction and analysis
  • BS degree required in a life science field, MS or PhD preferred
  • Minimum of 15 years of experience in biotech/pharmaceutical industry in the R&D and clinical development space, including 8+ years in project/portfolio leadership leading cross-functional matrix teams

Compensation

  • Our target starting salary for successful US-based applicants for this role is $264,000 - $298,000.
  • To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
  • This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

Benefits

  • Excellent medical, dental, and vision coverage as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • You will develop and execute high quality integrated project plans with clear timelines spanning research, discovery, clinical development, software engineering, and data science/machine learning.
  • All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
  • Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

Company info

  • We believe diversity, equity, and inclusion need to be at the foundation of our culture.
  • Deep experience leading matrix team meetings to enable collaboration, decision-making, and alignment with internal and external customers while leading all aspects of project scope, deliverables, risks, and resources

Equal opportunity

  • insitro is an equal opportunity employer.
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This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.