Formation Bio

Formation Bio

Associate Director, Pharmacology

Boston, MA; New York, NY · Director

Sponsorship not specified$178k-$232kDetected 23 days ago
SparkData AnalysisBusiness DevelopmentPharmacologyResearchExperimental DesignAnimal StudiesAnimal ModelsLeadershipCommunicationOrganizational Skills

About the role

  • About Formation Bio Formation Bio is a tech and AI driven pharma company differentiated by radically more efficient drug development.
  • The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, John Doerr, Spark Capital, SV Angel Growth, and others.
  • About the Position Formation Bio is seeking an Associate Director, Pharmacology to join our Development team.

Responsibilities

  • Design, oversee, and interpret pharmacology studies to characterize mechanism of action, target biology, in vivo proof of concept, dose-response, pharmacodynamic activity, exposure-response relationships, and asset progression
  • Develop integrated pharmacology plans covering efficacy, target engagement, receptor binding, selectivity, biomarkers, PK/PD, translational hypotheses, safety margins, therapeutic index, dose rationale, and key decision points
  • Apply first-principles scientific reasoning and broad pharmacology perspective to evaluate biological rationale, identify critical assumptions, pressure-test hypotheses, distinguish decision-critical data from interesting findings, and design focused studies to address key scientific, regulatory, or translational questions
  • Partner with DMPK, Toxicology, Clinical Pharmacology, Clinical Development, Regulatory, CROs, and external partners to integrate pharmacology into development strategy, regulatory materials, in-licensing evaluations, and interactions with regulators, partners, advisors, and internal leadership
  • Manage CRO-executed pharmacology studies and related workflows, including protocol review, vendor oversight, data quality, timelines, budgets, study conduct, interpretation, final reports, organizational tracking systems, and use of technology, modeling, data analytics, literature mining, and AI-enabled tools to improve speed, rigor, reproducibility, and decision-making
  • Strong first-principles scientific judgment, with evidence of original thinking, rigorous hypothesis generation, incisive experimental design, and the ability to interpret complex or ambiguous data
  • Experience developing pharmacology strategies that support candidate selection, IND-enabling work, clinical development, lifecycle management, regulatory submissions, or externally sourced assets
  • Experience working cross-functionally with DMPK, Toxicology, Clinical Pharmacology, Clinical Development, Regulatory, CROs, and external partners, including management of CRO-executed studies, protocols, data quality, timelines, budgets, and reports
  • Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients.

Nice to have

  • PhD in Pharmacology, Biology, Immunology, Translational Sciences, or a related field, with 4-6+ years of relevant post-PhD biopharma industry experience
  • level will be commensurate with experience
  • Broad, hands-on expertise in preclinical pharmacology, including mechanism of action, disease biology, in vivo efficacy models, dose-response, target engagement, biomarkers, selectivity, and PK/PD
  • Experience designing, overseeing, and interpreting animal studies, including model selection, endpoint strategy, dosing rationale, exposure-response relationships, and translational limitations
  • Strong understanding of how preclinical pharmacology informs translational hypotheses, dose rationale, safety margins, therapeutic index, biomarker strategy, and regulatory positioning
  • familiarity with immunology, immune-mediated disease biology, or immunomodulatory mechanisms preferred

Compensation

  • Range: $177,500 - $232,000
  • Individual compensation is determined by several factors, including role scope, geographic location, and skills & experience.
  • Your offer will reflect where you fall within the range based on these considerations.
  • In addition to base salary, we offer equity, comprehensive benefits, and generous perks.
  • If the posted range doesn't match your expectations, we still encourage you to apply!
  • Where We Hire Formation Bio is prioritizing hiring in key hubs, primarily the New York City and Boston metro areas, with a hybrid model requiring 3 days per week in office.

Benefits

  • Our Vision for AI in Pharma

Company info

  • Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials.
  • Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials.

Equal opportunity

  • Formation Bio is committed to building a diverse and inclusive team.
  • We are an equal opportunity employer and welcome candidates from all backgrounds.
  • All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, ancestry, sex (including pregnancy, childbirth, breastfeeding, and related medical conditions), gender identity or expression, sexual orientation, age, disability, genetic information, marital status, military or veteran status, or any other characteristic protected by federal, state, or local law.
  • Equal Opportunity Formation Bio is committed to building a diverse and inclusive team.
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