Adverum Biotechnologies

Senior Scientist, Downstream Process Development (Contract) - AW

Redwood City, CA · Senior

Sponsorship not specifiedDetected 89 days ago

ExcelRecruitingGMPCRISPRMolecular BiologyResearchLeadershipCommunicationProblem Solving

About the role

Note to Recruiters and Agencies All recruiter and agency inquiries must go through Adverum's internal Talent Acquisition team.
Unsolicited resumes sent to Adverum will be considered Adverum's property.
Adverum's Talent Acquisition team must expressly engage agencies for any requisition.

Support late‑stage AAV downstream process development and optimization to ensure scalability, robustness, reproducibility, and regulatory compliance.
Lead and execute purification development, including chromatography (AFF, IEX) and filtration (depth, NFF, TFF).
Individually and partner with other SMEs to author protocols and reports, and execute on process characterization and validation studies (FMEA, scale‑down models, DOE/OFAT, PPQ, hold studies).
Compile and analyze process and analytical data in Excel, JMP, or similar software, to identify trends, drive optimization, and lead and support investigations / RCA.
Support downstream material generation team as needed to maintain company timelines.
Downstream SME to support external manufacturing operations including technical meetings, BPR and related records review, execution, and troubleshooting.
Collaborate cross‑functionally (AD, USP, QC, RA) to ensure seamless transition from development to commercial.
Stay updated on industry trends and emerging technologies in gene therapy manufacturing to maintain best-in-class process development practices.
Excellent problem-solving skills with the ability to troubleshoot and optimize complex bioprocesses.
Strong communication and leadership skills to manage cross-functional projects and mentor team members.

Ph.D. in Biochemistry, Chemical Engineering, Molecular Biology, or related field with 4-6+ years of relevant experience in downstream process development
or M.S. with 8+ years of experience.
Proven experience in AAV or other viral vector production, preferably in late-stage development for clinical/commercial scale manufacturing.
Strong expertise and in-depth knowledge in functioning and troubleshooting of purification process development/manufacturing equipment such as chromatography and filtration systems.
Experience with scalable, AKTA, depth filtration, and TFF systems.
Knowledge of GMP requirements and regulatory guidelines for gene therapy products.
Prefer to have knowledge of DOE principles, process characterization, and BLA enabling activities.

Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases.

We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation

This listing is sourced directly from Adverum Biotechnologies's careers page and normalized into a canonical job model.