Tempus AI
Senior Software Engineer
Chicago · Senior
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odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$7,083 more — $117,083 — moves this role to Level II and 2 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $117,083 would place this position at wage Level II. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · Chicago-Naperville-Elgin, IL-IN. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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from this employer's Department of Labor filings
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Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives.
- This position requires deep expertise in full-stack engineering, relational data systems, bioinformatic workflow orchestration, and algorithmic development.
- As a senior technical leader, you will be expected to craft high-quality code, scale genomic data processing pipelines, leverage modern AI tooling, integrate APIs into user-facing applications, and embed agentic workflows into our core product ecosystem.
Responsibilities
- In this role, you will lead the analysis and design of complex technical problems, architect robust systems, and mentor emerging talent.
- Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.
- Our proprietary platform connects real-world evidence to deliver actionable intelligence to physicians, ensuring the right treatments reach the right patients at precisely the right time.
- We operate in small, autonomous teams where developers, designers, scientists, and product managers collaborate closely.
- You'll have direct ownership in building solutions that make a meaningful impact in cancer research and treatment.
Requirements
- Experience with React development with a demonstrated ability to design and implement complex component systems.
- Ability to make high-impact architectural decisions that balance business needs, data infrastructure constraints, and scientific computing requirements.
- Experience with search technologies such as Elasticsearch or OpenSearch.
- Experience with containerization orchestration (Docker, Kubernetes).
Skills
- 5+ years of advanced TypeScript/JavaScript/python development with a deep understanding of language features and optimization techniques.
- Extensive experience architecting and leading development with Node.js and NestJS frameworks.
- Hands-on experience managing, monitoring, and optimizing workflow executions via Seqera Platform (Nextflow Tower) across cloud environments.
- Experience or strong working knowledge of integrating APIs and GenAI technologies into production applications.
- Advanced PostgreSQL skills including query optimization, indexing strategies, and performance tuning.
- Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
- What Makes You a Great Fit
- 7+ years of software development experience with a track record of technical leadership.
Compensation
- The expected salary range may vary for other locations.
Benefits
- Passionate about precision medicine and advancing the healthcare industry?
- At Tempus, we're leveraging cutting-edge technology to transform healthcare through AI-powered insights.
Company info
- Join the Revolution in Precision Medicine At Tempus, we're leveraging cutting-edge technology to transform healthcare through AI-powered insights.
- About the Role We are seeking a highly motivated and capable Senior Software Engineer to help advance our Diagnostics initiatives.
This listing is sourced directly from Tempus AI's careers page and normalized into a canonical job model.