Glyphic Biotechnologies
Scientist, Applications Sample Preparation
Berkeley, CA · Full-time
Sponsorship not specified$90k-$130kDetected 1 day ago
PythonData AnalysisData SciencePCRqPCRMolecular BiologyNGSCell CultureResearchMass SpectrometryCommunicationProblem SolvingAdaptability
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47Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level II)66
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~30% per draw at Level II). Good if you win; have a cap-exempt backup on your list.
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About the role
- A track record of hands-on sample prep execution across proteomics and NGS platforms, and comfort operating in high-throughput environments, will be key to making an immediate impact.
- This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.
- This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
Responsibilities
- Apply and adapt enrichment, depletion, and dynamic-range management protocols to improve input quality for low-abundance targets and optimize ProSE and NGS sequencing yield.
- Perform core molecular biology reactions - buffer preparation, reagent formulation, enzymatic reactions, gel electrophoresis, PCR/qPCR, hybridization-based assays, and amplification workflows - to prepare samples for downstream analysis.
- Support the generation and sourcing of standard reference materials using cell culture techniques.
- Test protocol variables - reagent concentrations, incubation times, temperature conditions, wash conditions, sample preparation steps, and workflow timing - to optimize assay performance.
- Propose and apply in-process controls and analytical tools to build a comprehensive understanding of the factors driving sequencing efficiency across diverse sample and molecule types.
- Collaborate closely with proteomics, assay development, chemistry and data science teams to design experiments, interpret results, and guide project strategy - including cross-platform efforts (ProSE, RNA-seq, DNA-seq, ribosome profiling, and mass spectrometry).
- Clear written and verbal communication skills, with the ability to collaborate effectively across diverse scientific and technical backgrounds.
- At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting.
- We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease.
Requirements
- Degree in biochemistry, chemical biology, molecular biology, or an equivalent field
- Proficiency with NGS library preparation methods (DNA-seq, RNA-seq, and/or ribosome profiling), including nucleic acid extraction, quantification, amplification, and QC.
Nice to have
- Experience with chemical labeling or modification chemistries (e.g., side-chain labeling, ABPP, or similar chemoproteomic approaches) as applied within established sample preparation workflows.
- Deep familiarity with highly multiplexed, high-sensitivity protein quantification platforms (e.g., nELISA, NuLISA, immunoassays, PLA, or PEA).
- Experience with nanopore platforms for sequencing or label-free detection.
- Experience with single-cell or spatial proteomics and transcriptomics.
- Familiarity with neoantigen discovery workflows that integrate genomic, transcriptomic, and proteomic evidence.
- Comfort working in R or Python to input experimental results into and navigate established data analysis workflows.
- Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
- Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Skills
- Contribute to first-of-their kind technologies, high-impact publications, and patents
Compensation
- Estimated Base Salary $90,200 - $129,500
- This is the pay range for this position that we reasonably expect to pay.
- Individual compensation is based on various factors including, experience, education, skillset, and geographic location.
Benefits
- Employee Stock Option Plan
- 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
- Employer Retirement Contributions to 401(k)
- Generous Paid Time Off
- Paid Maternity and Paternity Leave
- Health & Wellbeing Program
- To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
Company info
- Direct impact on product development and company direction
Equal opportunity
- We are an Equal Opportunity Employer.
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