Raven
Raven StealthCo- Director, Oligonucleotide and Conjugation Chemistry
Boston, MA, USA · Director
Sponsorship not specified$210k-$235kDetected 7 days ago
Intellectual PropertyClinical TrialsResearchMass SpectrometryAnimal StudiesAnimal ModelsLeadershipProblem SolvingAdaptabilityOrganizational Skills
About the role
- The Director, Oligonucleotide and Conjugation Chemistry will report directly to the VP of Delivery and will interface frequently with company leadership and cross-functional teams to advance oligonucleotide therapeutic programs.
- Oversee chemistry aspects of the development of oligonucleotide conjugates for biological evaluation in our targeted delivery platform
- Work closely with company leadership, contributing to scientific strategy and assisting in preparing materials (data reviews, presentation decks) for internal and external constituents; participate in external discussions, as directed
Responsibilities
- Manage external chemical synthesis activities which may include oligonucleotide synthesis; small-molecule, lipid, and peptide ligand synthesis; linker synthesis; and oligonucleotide-conjugate synthesis
- Build internal lab capabilities and lead a team of conjugation and analytical scientists to prepare, purify, and analytically characterize oligonucleotide conjugates, particularly antibody-oligonucleotide conjugates
- Work cross-functionally with protein engineers and biologists to ensure timely and adequate preparation of oligonucleotide conjugates for biological evaluation as well as to contribute to the design of in vitro and in vivo studies
- Contribute to intellectual property around the design of oligonucleotides and oligonucleotide conjugates for the company
- The Director, Oligonucleotide and Conjugation Chemistry should be a doer with a "roll up their sleeves" mentality while having the ability to manage people and interpret complex scientific data efficiently and effectively.
- They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you.
- RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond.
- We are building
- a platform to deliver oligos with high precision to previously untargeted cells, while focused on "undruggable" genes, alone or in combination with previously validated targets.
Requirements
- PhD. in chemistry or related discipline with 8+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry
- or BS/MS with 12+ years
- Experience managing both internal personnel and external CROs to advance oligonucleotide therapeutics
- Demonstrated ability to work cross-functionally to plan and coordinate in vitro and in vivo studies to evaluate oligonucleotide and/or antibody/peptide-conjugate modalities
- Imperative that this individual be an effective communicator and proven team-builder, mentor, motivator, and manager
- The Director, Oligonucleotide and Conjugation Chemistry must be highly organized, thoughtful, and bring sound judgement and decision-making abilities.
- PhD. in chemistry or related discipline with 8+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 12+ years
- Ideal candidate will have experience developing peptide-, protein-, or antibody-oligonucleotide conjugates while effectively operating in cross-functional, collaborative environments
- Adept in state-of-the-art conjugation (cysteine-maleimide, click chemistry, site-specific, etc.), purification (HPLC, SEC, IEX, etc.), and analytical (HPLC, LCMS, etc.) methods to prepare oligonucleotide conjugates
- While demonstrating creativity to contribute to the discovery of novel delivery systems, this individual must also be process- and detail-oriented to ensure production of high-quality oligonucleotide conjugates
Compensation
- The base salary range reflects our good faith estimate at the time of posting.
Benefits
- Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies.
Company info
- At a personal level, we are seeking an individual who is highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style.
- The company is creating a culture of highly engaged colleagues who put the team and the science above the self and operate with a sense of urgency.
- From an educational perspective, we are seeking an individual with a Ph.D. and/or BS/MS in a relevant discipline such as chemistry or protein engineering.
- This person will be based on-site at the company's headquarters in Cambridge, MA.
- We are a well-funded, stealth-mode biotechnology focused on next generation oligo-based modalities targeting tissues beyond the liver, muscle, and kidney.
This listing is sourced directly from Raven's careers page and normalized into a canonical job model.