Flagshippioneeringinc

Pioneering Medicines: DMPK Project Lead

Cambridge, MA USA

Sponsorship not specified$148k-$237kDetected 7 days ago

ComplianceSupply ChainRecruitingIntellectual PropertyAnimal StudiesLeadershipCommunicationCollaborationProblem SolvingAdaptability

About the role

We are seeking a highly motivated and experienced DMPK project representative to join our growing team.
The ideal candidate brings deep expertise in DMPK, bioanalysis (BA), and immunogenicity science, with a proven ability to influence discovery and development strategies for biologics.
This is a high-impact role requiring strong analytical thinking, scientific rigor, and exceptional communication skills.

Serve as the DMPK representative on cross-functional discovery teams to guide PK, BA and immunogenicity strategies that support project decisions and milestones.
Design and lead in vitro and in vivo PK/BA/Immunogenicity studies to characterize biologics and support candidate progression.
Collaborate with internal and external stakeholders to plan and execute DMPK deliverables with high quality and efficiency.
Collaborate with PK/PD modelers to establish PK/PD correlations and guide preclinical study design.
Contribute to the selection of preclinical toxicology species and develop the toxicokinetic plan to support IND filing.
Support human dose projections based on preclinical data to guide candidate selection.
Provide operational oversight for quality and performance of DMPK activities, including interactions with CROs and external project support.
You will collaborate closely with multi-disciplinary teams to optimize candidate selection, design and execute preclinical studies, and ensure regulatory readiness.

PhD. in pharmaceutical sciences, biochemistry, or related field with 8+ years of relevant industry experience
or M.S. with 12+ years
or B.S. with 14+ years.
Proven track record representing DMPK in biologics discovery and/or development programs.
Extensive hands-on experience with PK, BA, and immunogenicity assessment of biologics.
Working knowledge of regulatory expectations and experience contributing to submissions.
Experience in managing CROs and external study oversight.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent.
Strong publication and/or patent record demonstrating scientific leadership.
Demonstrated success in cross-functional team environments, with strong collaboration, communication, and presentation skills.
Adaptable, detail-oriented, and able to manage multiple priorities in a fast-paced setting.
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.

Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
The salary range for this role is $148,000 - $236,500.

vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

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