Insitro
Senior/ Staff Software Engineer, Imaging
South San Francisco, CA · Staff+
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odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$2,149 more — $193,149 — moves this role to Level III and 3 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $193,149 would place this position at wage Level III. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
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About the role
- insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients.
- Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics-whether small molecules, biologics, or oligos.
- With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.
Responsibilities
- Platform Enablement: Partner with lab and ML scientists to design, develop, and scale the platform capabilities needed to run and interpret ML-powered high-content imaging screens.
- User Tooling: Build and evolve robust tools and interactive interfaces for data exploration, quality assessment, and visualization so scientists can iterate quickly on experimental data.
- Architectural Ownership: Own complex, end-to-end projects, making thoughtful architectural trade-offs, and delivering incrementally with long-term maintainability in mind.
- Documentation: Write clear, exemplary technical specifications and documentation that others build on.
- Senior/ Staff experience: 6+ years of professional experience building and operating production-grade software and high-throughput data pipelines, primarily in Python.
- You'll build the platform features that make novel in vitro screening modalities and ML-derived phenotypes integral to our discovery workflows, partnering with lab scientists, ML scientists, and our automation teams to turn research prototypes into validated screening workflows that reliably process terabytes of biological data per day.
- Partner with lab and ML scientists to design, develop, and scale the platform capabilities needed to run and interpret ML-powered high-content imaging screens.
- We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease.
- These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism.
- Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners.
Requirements
- A track record of owning complex systems from architecture through production operation.
- You enjoy mentoring and leveling up the engineers around you.
- Force Multiplier: You enjoy mentoring and leveling up the engineers around you.
Compensation
- Our target starting salary for successful US-based applicants for this role is $191,000 - $233,000.
- To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity.
- This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
Benefits
- Excellent medical, dental, and vision coverage as well as mental health and well-being support
- Open, flexible vacation policy
- Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)
- New hire stipend for home office setup
- Monthly cell phone & internet stipend
- This is a chance to set the technical direction for how imaging, automation, machine learning, and agentic analysis converge in drug discovery.
- All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
- Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area
- Based in South San Francisco, this position reports directly to the Director of Imaging, Cellular Machine Learning and offers an in-person hybrid schedule of three days per week.
Company info
- We believe diversity, equity, and inclusion need to be at the foundation of our culture.
Equal opportunity
- insitro is an equal opportunity employer.
This listing is sourced directly from Insitro's careers page and normalized into a canonical job model.