Novartis

Novartis

Associate Director, Translational Modeling & Simulation

Cambridge (USA) · Director

Sponsorship not specifiedDetected 70 days ago
MATLABAlgorithmsData EngineeringAgentic AIClinical TrialsPharmacologyResearchAnimal StudiesCommunicationCollaborationMentoring

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Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70

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About the role

  • Act as the M&S representative on several programs.
  • Novartis is a leader in neuroscience and cardiovascular disease areas with a robust and diverse pipeline of innovative therapies.
  • We are seeking a translational modeler eager to accelerate oligonucleotide therapeutics (xRNA"), including antibody-xRNA conjugates, from discovery through clinical translation.

Responsibilities

  • Act as the M&S representative on several programs. Develop and execute modeling strategies, contribute to project team discussions, and guide model-informed decisions from therapeutic design to first-in-human dose selection and beyond.
  • Build and apply mechanistic models (PK/PD, QSP, and PBPK/PD) that link drug pharmacology, tissue biodistribution, mechanism(s) of action, and downstream effects.
  • Integrate modeling into the design and interpretation of preclinical in vivo and in vitro studies to support candidate selection, optimization, and advancement towards the clinic.
  • Collaboratively develop platform disease (QSP) and PBPK/PD models that extend across multiple projects and phases of discovery & development.
  • Engage in strategic initiatives within M&S, such as creating platform-level translational modeling strategies tofor new platformsthat impact across projects and developing new and modeling workflows (e.g., agentic AI).
  • Proactively seek opportunities to increase the understanding and adoption of translational modeling among internal partners and expand the impact and visibility of modeling through external collaborations.
  • We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Requirements

  • Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or a related field and 7+ years of industry experience with progressively increasing levels of responsibility.

Nice to have

  • Industry Modeling Skills: Expert level proficiency in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or mechanistic physiologically based PK/PD (PBPK/PD) is required.
  • Domain Expertise: Prior experience with the integration of computational modeling and biological concepts is required.
  • Role-specific experience in the highlighted disease areas (neuroscience, cardiovascular, metabolism) and drug modalities (oligonucleotides, ADCs) is preferred but not required.

Skills

  • Proficiency in pharmacometrics concepts (Population PK, exposure-response modeling) is preferred.
  • Prior experience with the integration of computational modeling and biological concepts is required.
  • Collaboration and Communication:
  • Fluent in English (oral and written).
  • Algorithms, Clinical Trials, Data Engineering, Innovation, Mentorship, Simulation Software, Waterfall Model
  • Industry Modeling
  • The salary for this position is expected to range between: $152,600 and $283,400 per year.
  • Novartis may change the published salary range based on company and market factors.
  • In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • EEO Statement:
  • The Novartis Group of Companies are Equal Opportunity Employers.
  • Accessibility and reasonable accommodations

Compensation

  • $152,600 and $283,400 per year.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.
  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
  • $152,600.00 - $283,400.00

Benefits

  • US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
  • To learn more about the culture, rewards and benefits we offer our people click here.

Equal opportunity

  • The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
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This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.