Korro Bio
Senior Associate Scientist, In Vivo Pharmacology
60 First St, Cambridge, MA 02141 · Senior
Sponsorship not specified$109k-$130kDetected 27 days ago
Data AnalysisExcelCustomer SupportPharmacologyClinical Laboratory TechniquesPCRqPCRMolecular BiologyCell CultureExperimental DesignProtein AnalysisAnimal StudiesCommunicationProblem SolvingPublic SpeakingMicrosoft Office
About the role
- By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.
- Korro is based in Cambridge, Massachusetts.
- They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.
Responsibilities
- Independently design and conduct routine and non-routine experiments to determine the efficacy of novel oligonucleotides in rodent models across a range of disease indications.
- Perform dosing via subcutaneous (SC), intraperitoneal (IP) and intravenous (IV) routes
- Provide overall in vivo and ex vivo technical support for projects working to advance one or more experimental therapeutic compounds.
- Serve as the subject matter expert on cross-functional project teams, providing scientific guidance on study design, data interpretation, and alignment with program needs, informed by ongoing review of relevant scientific literature.
- Develop, optimize, and execute ELISA and hELISA assays to quantify target proteins, biomarkers and therapeutic candidates in biological matrices.
- Support bioanalytical method development activities for the measurement of drug concentrations and pharmacodynamic endpoints in plasma, serum, and tissue samples.
- Collaborate cross functionally with Discovery Chemistry, Translational Biology, and DMPK teams to support exposure response analyses and inform compound progression decisions and recommend future scientific direction.
- Maintain meticulous records of all experimental procedures, raw data, and results in electronic laboratory notebooks (ELN).
- Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform.
- Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit.
Requirements
- M.S. or B.S. in Biology, Biochemistry, Pharmacology, or a related life sciences discipline, with 5+ years of relevant experience (M.S.) or 8+ years of relevant experience (B.S.) required.
- Knowledge of tissue processing and molecular biology methods including RNA purification, PCR, qPCR, sequencing, protein isolation, MSD, western blot.
- Knowledge of cardiometabolic/obesity models or experience with rodent models requiring low-stress handling is highly desirable.
- Proficiency in standard laboratory techniques including cell culture, aseptic technique, and sterile handling of biological samples.
- Experience with data analysis and visualization software such as Graph Pad Prism, Microsoft Office (including Excel) for summarizing and presenting pharmacology and bioanalytical data.
- Familiarity with electronic laboratory notebooks (ELN) for data recording and experiment documentation.
Nice to have
- Experience with bioanalytical method development and execution in support of in vivo and in vitro pharmacology or ADME studies is a plus.
Compensation
- Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending acc
Benefits
- We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.
- Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
- monitor animal health, collect blood samples, harvest multiple tissues, and coordinate sample storage and analysis.
Company info
- We are collaborative and united by a common mission.
- Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.
Apply directly at Korro Bio →Create a free account for alerts like thisView Korro Bio immigration profile
This listing is sourced directly from Korro Bio's careers page and normalized into a canonical job model.