AskBio Inc
Principal Scientist, Delivery
Durham, NC · Principal
Sponsorship not specifiedDetected 30 days ago
Data AnalysisRecruitingBioinformaticsCRISPRMolecular BiologyNGSResearchExperimental DesignAnimal StudiesLeadershipCommunicationMentoring
About the role
- The role is based in Research Triangle Park, NC.
- You are a highly independent scientific thinker who thrives in ambiguity and can take an abstract biological or technical question and turn it into a clear, executable experimental strategy.
- You operate as a go‑to expert in your domain, influencing decisions through data quality, clarity of thinking, and scientific judgment.
Responsibilities
- The Principal Scientist will operate as a scientific leader and people leader, providing strategic and technical direction for capsid library design, screening, and characterization efforts.
- Define and drive innovative capsid screening and characterization strategies, independently conceiving new experimental approaches to improve transduction, specificity, and translational relevance
- Ensure rigorous scientific oversight of capsid library screening campaigns, including experimental design, data interpretation, and translation of results into clear candidate‑selection recommendations
- Own scientific direction, priorities, timelines, and decision‑making across multiple capsid‑focused workstreams, proactively identifying risks and driving solutions to ensure timely delivery
- Pioneering science to create transformative molecular medicines.
Requirements
- PhD in Molecular Biology, Virology, Biotechnology, Gene Therapy, or related discipline with 8+ years of relevant experience (may include postdoctoral training)
- Demonstrated hands‑on experience with AAV capsid library screening, including pooled or barcoded libraries and NGS‑based analysis
- Demonstrated experience in leading others in direct line management or matrix style roles
- Strong experience in AAV production, purification, and QC supporting discovery and preclinical research
- Proven experience leading complex scientific projects with broad scope and minimal day‑to‑day supervision
- Experience with in vivo capsid selection, biodistribution studies, and tissue‑level analysis
- Experience with CNS capsid discovery, in addition to other tissue targets
- Experience with non-viral modalities
- Familiarity working closely with bioinformatics teams for analysis and interpretation of large NGS datasets
- Experience contributing to capsid, vector, or delivery platform strategy in a gene therapy or advanced R&D setting
Benefits
- You have experience leading people and thrive in cross-functional teams, leading without detailed instruction and able to balance strategic vision with hands-on scientific depth.
Company info
- Lead innovative science and drive clinical outcomes to transform people's lives.
- Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
- Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
- Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
- Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
- Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.
- Our principles:
- Advance innovative science by pushing boundaries.
- Bring transformative therapeutics to patients in need.
- Provide an environment for employees to reach their fullest potential.
- AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives.
- The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson's disease, and Pompe disease.
- AskBio's gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters.
- With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.
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