Capable

Capable

Program Lead, Therapeutic Discovery

San Francisco

Sponsorship not specified$180k-$340kDetected 25 days ago
Clinical TrialsExperimental DesignAnimal StudiesAnimal ModelsCollaborationMentoring

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odds of building a lasting career here

37Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

No strong sponsorship signal in the public record yet. In the full product we resolve the exact legal entity and show its filing history with a confidence score — treat as unverified until then.

Lottery odds assume a STEM candidate.

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About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Not only develop proposals but also execute: target selection, literature review, experimental design, molecule design or sourcing, assay development, in vitro testing, in vivo testing, data review, and next-round program decisions in close collaboration with our scientific team.
  • For promising programs, help build the team and infrastructure around them: hire scientists, identify advisors, select partners, source animal models, procure instrumentation, and manage execution.
  • Lead programs while remaining close to the science and data. For strong programs, we can commit significant early validation capital-up to $1M for initial experiments, and substantially more if data support continued investment.
  • Lead new therapeutic programs from concept through early validation.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • You are high-agency, precise, skeptical, and execution-oriented.

Compensation

  • $180,000-$340,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $180,000-$340,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • These may include programs in contraception, menstrual suppression, stress resilience, cognition, exercise mimetics, recovery, sleep, or other areas where biology could meaningfully expand human health and capability.
  • Bring forward ambitious, scientifically grounded program ideas aimed at meaningfully expanding human health or capability.
  • You are motivated by high-impact biological problems-including sleep, cognition, reproductive health, disease resistance, recovery, aging, and the physiological constraints on human performance and health.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • Ideally, you have created or helped create a drug candidate that has advanced into clinical trials or reached the market.
  • You have previously originated and advanced your own scientific programs, not just contributed to others' roadmaps. You can provide examples where you identified a promising mechanism or opportunity, designed the experimental path, drove execution, and produced concrete outcomes-meaningful data, decisions, publications, patents, products, funding, or similar.
  • You have strong scientific judgment and are able to critically evaluate papers, mechanisms, phenotypes, or therapeutic ideas to determine their potential as real programs, including defining targets, modalities, assay plans, biomarkers, model systems, translational paths, and decision points.
  • You are high-agency, precise, skeptical, and execution-oriented. You move quickly while maintaining scientific rigor.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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This listing is sourced directly from Capable's careers page and normalized into a canonical job model.