Ginkgo Bioworks

Ginkgo Bioworks

Senior Engineer III, ADME

Boston, Massachusetts · Senior

Sponsorship not specifiedDetected 126 days ago
PythonData AnalysisData VisualizationPharmacologyMass SpectrometryLeadershipMentoring

About the role

  • Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe's growing challenges in health, energy, food, materials, and more.
  • The base salary range for this role is $185,000k - $278,800k Actual pay within this range will depend on a candidate's skills, expertise, and experience.

Responsibilities

  • Design, develop, optimize, and validate a wide array of high-throughput in vitro ADME assays (e.g., solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction).
  • Develop and perform mass spectrometry (LC-MS/MS, acoustic ejection mass spectrometry, or similar) analysis of samples from ADME assays. Responsibilities will include method development and troubleshooting.
  • Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks.
  • Build and maintain "buttoned‑up" SOPs, runbooks, checklists, and QC dashboards for all established assays.
  • Collaborate with computational and data teams on metadata schemas, QC metrics, and analysis‑ready outputs.
  • Work closely with program leads to scope work, set expectations, and communicate progress and risks.
  • Document methods, "tips & tricks", and troubleshooting guides; lead trainings and onboarding sessions.
  • Proven track record in developing and running automated in vitro ADME assays using state-of-the-art laboratory automation.

Requirements

  • Technical Expertise:
  • Extensive, hands-on experience with LC-MS or acoustic MS particularly in a high-throughput setting.
  • Strong theoretical and practical knowledge of drug metabolism pathways and DMPK.
  • Familiarity with common ADME prediction software and data visualization tools.
  • Experience using lab automation.
  • Programmatic coding experience (e.g., Python, R, or similar).
  • Ginkgo has implemented a return to office policy effective October 1, 2025 with required in-office days 3x per week on Tuesday, Wednesday, Thursday.
  • Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 7+ years of relevant industry experience, or a Master's degree with 12+ years of industry experience.

Nice to have

  • Preferred Skills

Skills

  • Ensure proper sample preparation and management for high-throughput analysis.
  • Analyze, interpret, and report complex ADME data, including calculating key pharmacokinetic parameters.
  • Present results and provide expert recommendations to medicinal chemists and project teams to inform go/no-go decisions.
  • Ensure all laboratory activities comply with internal quality standards and safety regulations.
  • Lead day‑to‑day operations of the ADME team
  • Contribute to portfolio and capacity planning, including scenarios for large campaigns.
  • Provide technical leadership and day‑to‑day guidance for scientists on ADME workflows.
  • Contribute to the Datapoints skill matrix by defining training levels, shadowing plans, and up‑leveling team members on key assays

Compensation

  • The base salary range for this role is $185,000k - $278,800k Actual pay within this range will depend on a candidate's skills, expertise, and experience.
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