Flagshippioneeringinc
Director/Senior Director, Computational Chemistry
Cambridge, MA USA · Director
Sponsorship not specified$176k-$294kDetected 1 day ago
Machine LearningData ScienceComplianceRecruitingPharmacologyAnimal StudiesLeadershipCommunicationCollaboration
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Lottery odds (Level IV)94
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About the role
- FL111 is seeking a Director/Senior Director, Computational Chemistry to spearhead the design and optimization of heterobifunctional small molecules.
- This leader will work closely with medicinal chemists, structural biologists, and project teams to develop and apply computational tools to guide molecular design decisions across the design-build-test-learn cycle.
- The successful candidate will drive molecular ideation, property optimization, and compound prioritization across the portfolio.
Responsibilities
- Cheminformatics & Library Exploration: Lead and direct cheminformatics strategy to identify and prioritize chemical series
- oversee development of internal computational workflows and data infrastructure to support program needs
- ADME & Developability Assessment: Direct evaluation of key molecular (e.g., solubility, permeability, lipophilicity, clearance risk) and lead compound prioritization frameworks that systematically integrate developability considerations across the portfolio.
- Structure-Based & Computational Modeling: Champion and advance structure-based and AI/ML-assisted modeling capabilities (e.g., docking, conformational analysis, FEP) to inform ligand selection, attachment strategy, and linker design
- drive adoption of emerging computational methods across the organization.
- Cross-Functional Collaboration: Serve as a strategic scientific partner and computational chemistry leader across chemistry, biology, and in vivo pharmacology teams within the company
- Proven scientific leadership and communication skills: demonstrated ability to build, lead, and inspire interdisciplinary teams and influence senior stakeholders.
- Cheminformatics & Library Exploration: Lead and direct cheminformatics strategy to identify and prioritize chemical series; oversee development of internal computational workflows and data infrastructure to support program needs
Requirements
- PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or a related discipline, with 10+ years of relevant industry experience, including demonstrated scientific leadership and people management experience.
- Deep expertise in computational medicinal chemistry and structure-based drug design in the binary and ternary settings, with a track record of driving impactful decisions across multiple drug discovery programs.
- Demonstrated ability to drive and evaluate real, synthetically actionable molecular designs and to mentor and develop scientists to do the same.
- Experience using cheminformatics tools for compound design, analysis and prioritization.
Skills
- Prior experience working on heterobifunctional small molecules (e.g., PROTACs) is preferred
- Familiarity with ADME optimization challenges for large, flexible molecules is strongly preferred.
- Prior experience in an early-stage or startup biotech environment is preferred.
- About Flagship Pioneering
- Learn more about Flagship at www.flagshippioneering.com.
Compensation
- FL111 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
Benefits
- and benefits information is based on FL111's good faith estimate as of the date of publication and may be modified in the future.
Company info
- Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry, computation, and data science to create new therapeutic modalities beyond traditional small molecules.
- FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact.
- We are seeking collaborative, creative and relentless problem solvers that share our passion for impact to join us!
Visa & Work Authorization
- California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information.
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