AskBio Inc
Sr. Research Associate, Delivery
Durham, NC · Senior
Sponsorship not specifiedDetected 30 days ago
Data AnalysisStatisticsExcelRecruitingPCRqPCRCRISPRMolecular BiologyNGSCell CultureResearchProtein AnalysisWestern BlottingAnimal StudiesCommunicationProblem SolvingPublic SpeakingOrganizational SkillsMicrosoft Office
About the role
- The Senior Research Associate will work directly with the non-viral delivery team to conduct experiments that advance our preclinical therapeutic pipeline.
- This position is based in Morrisville, North Carolina.
- Conduct small-scale LNP formulation and analytical characterization for early research and preclinical in vivo and in vitro studies
Responsibilities
- Develop detailed experimental protocols and maintain an electronic laboratory notebook in accordance with good documentation and data integrity practices
- Maintain inventory and order reagents and materials to support timely project execution
- Pioneering science to create transformative molecular medicines.
Requirements
- Bachelor's degree in molecular biology, Biochemistry, or a related field with 5+ years of research experience
- OR a Master's degree in molecular biology, Biochemistry, or a related field with 2+ years of research experience
- Hands-on experience with molecular biology techniques, including DNA/RNA isolation, SDS-PAGE, qPCR, and Western blot
- Experience with cell line maintenance, including primary cell culture
- Strong technical laboratory skills with the ability to independently execute protocols and experiments
- Ability to follow established molecular biology SOPs with minimal supervision
- Proficiency in Microsoft Office Suite (Word, Excel, PowerPoint)
- Experience with research-grade LNP formulation and analytical characterization
- Experience with next-generation sequencing (NGS)
- Experience using SnapGene and GraphPad
Nice to have
- Prior experience with research-grade lipid nanoparticle (LNP) formulation is preferred.
Company info
- Lead innovative science and drive clinical outcomes to transform people's lives.
- Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
- Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
- Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
- Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
- Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.
- Perform plasmid purification, genomic DNA extraction, RNA extraction, and PCR-based assays (PCR, qPCR, ddPCR)
- Perform in vitro cell-based assays, including plasmid transfection, AAV transduction, LNP transfection, and primary cell culture
- Analyze data and effectively communicate results through formal reports and presentations for internal and external stakeholders
- Ensure laboratory areas are clean, organized, and adequately stocked with necessary equipment and supplies
- Bachelor's degree in molecular biology, Biochemistry, or a related field with 5+ years of research experience; OR a Master's degree in molecular biology, Biochemistry, or a related field with 2+ years of research experience
- Our principles:
- Advance innovative science by pushing boundaries.
- Bring transformative therapeutics to patients in need.
- Provide an environment for employees to reach their fullest potential.
- AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives.
- The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson's disease, and Pompe disease.
- AskBio's gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters.
- With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.
- Clear understanding of in vivo gene therapy approaches, including adeno-associated virus (AAV) and lipid nanoparticles (LNP)
- Ability to manage multiple projects simultaneously and work independently in a fast-paced, collaborative environment
- Highly organized, self-motivated, and able to work both independently and within cross-functional teams
- Excellent written and verbal communication skills, including accurate documentation practices
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