Capable

Capable

Principal Scientist, Therapeutic Discovery

San Francisco · Principal

Sponsorship not specified$180k-$340kDetected 24 days ago
Data AnalysisResearchExperimental DesignMentoring

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odds of building a lasting career here

37Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

No strong sponsorship signal in the public record yet. In the full product we resolve the exact legal entity and show its filing history with a confidence score — treat as unverified until then.

Lottery odds assume a STEM candidate.

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About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Lead therapeutic research programs from conceptualization through early validation in areas such as contraception, stress resilience, cognition, exercise mimetics, recovery, and sleep.
  • Execute all stages of the research lifecycle: hypothesis development, literature review, experimental design and execution, data analysis, and program evaluation, collaborating closely with scientific colleagues.
  • Assemble and manage interdisciplinary teams, identify advisors and collaborators, source models and equipment, and oversee research operations.
  • Maintain direct involvement with experimental data and program strategy. Capable Labs provides significant funding for projects showing strong foundational evidence.
  • You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.
  • We value speed and rigor, coupled with excitement, drive, and a strong work ethic.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • You have a strong academic record and have led or significantly contributed to drug discovery or therapeutic programs progressing towards clinical application.

Compensation

  • $180,000-$340,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $180,000-$340,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • Develop rigorous, scientifically grounded research proposals that address crucial questions in human health and capability.
  • Your research interests span impactful biomedical topics including sleep, cognition, reproductive health, disease resistance, recovery, aging, and the biological determinants of health.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • ABOUT THE ROLE We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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