Prime Medicine
Senior Scientist, Safety Assessment
Cambridge, MA · Senior · Full-time
Sponsorship not specified$145k-$161kDetected 8 hours ago
PharmacologyCRISPRLeadershipCommunicationCollaborationOrganizational Skills
About the role
- Contribute to nonclinical safety activities as part of cross-functional Discovery and Development project teams, supporting program progression through IND-enabling stages.
- Assist in identifying potential safety findings and contribute to discussions on data interpretation and next steps.
- Ensure studies and internal activities are conducted in compliance with regulatory guidelines and internal standards.
Responsibilities
- Design, execute, and troubleshoot nonclinical safety studies, including hands-on laboratory work (~30%) to support assay development, data generation, and issue resolution.
- Support the execution and oversight of nonclinical safety studies (GLP and non-GLP) at CROs, including active involvement in troubleshooting assay and study-related challenges.
- Collaborate with Pharmacology, DMPK, and other functions to support exploratory studies (e.g., exploratory toxicology, DMPK, biodistribution, and delivery platform evaluation).
- Contribute to evaluation of new delivery approaches, Lipid and RNA components, and emerging targets to support pipeline expansion.
Nice to have
- Experience in large molecule therapeutic development, along with a background in immunology, is desirable.
- Understanding of toxicology principles, nonclinical safety evaluation, and the drug development process, with some experience interpreting toxicology data and contributing to technical and scientific reports.
- Demonstrates strong scientific judgment and leadership with the ability to evaluate information, identify potential issues, and propose practical solutions with guidance as needed.
- Highly organized and detail-oriented with strong attention to accuracy and quality.
- Experience supporting nonclinical studies at CROs is preferred but not required.
- Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
Compensation
- $145,000 - $161,000 USD
Equal opportunity
- Prime Medicine is proud to be an equal opportunity employer.
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