Twist Bioscience
Manager, Site Reliability Engineer
USA - South San Francisco, CA · Senior
Stay score
odds of building a lasting career here
Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
Personalize to your clock →H-1B wage level
the lottery is wage-weighted — each level is one more entry
$10,804 more — $221,187 — moves this role to Level IV and 4 lottery entries. That figure is inside the range the employer already advertised.
Based on the DOL prevailing wage for this occupation and worksite, a base salary of $221,187 would place this position at wage Level IV. That figure is within the posted range, and I'd like to target it. This role classifies under "Software Developers" for prevailing-wage purposes.
DOL prevailing wage, 2026-27 wage year · Software Developers (15-1252) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
Employer immigration record
from this employer's Department of Labor filings
Files H-1B transfers
Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.
Community outcomes
No reports yet — be the first to help the next applicant.
About the role
- This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications.
- The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence.
Responsibilities
- Lead and manage the Site Operations / SRE function
- Own cloud infrastructure architecture, operations, scalability, and optimization
- Drive operational excellence through automation, monitoring, and incident management
- Develop and maintain observability platforms including logging, metrics, alerting, and tracing
- Manage Kubernetes-based infrastructure and container orchestration environments
- Collaborate with software engineering teams to improve deployment processes, system resilience, and performance
- Lead incident response, root cause analysis, and post-incident remediation efforts
- Manage vendor and platform relationships where applicable
- Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement
- Define and implement infrastructure security and compliance best practices
Requirements
- 5-7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles
- Prior experience leading or mentoring engineering or operations teams
- Strong hands-on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP)
- Experience managing Kubernetes (K8s) environments in production
- Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies
- Experience with Akamai CDN administration and optimization
- Experience with observability and monitoring platforms, including Splunk
- Experience with storage infrastructure and cloud-native storage solutions
- Strong scripting and automation experience (Python, Bash, Terraform, or similar)
- Experience implementing and maintaining CI/CD pipelines
Nice to have
- Experience with infrastructure-as-code and GitOps methodologies
- Familiarity with security best practices and compliance frameworks
- Experience supporting highly available enterprise or SaaS platforms
- Strong understanding of container security and cloud-native architectures
- About Twist Bioscience
- Twist Bioscience synthesizes genes from scratch, known as "writing" DNA.
- Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
- Twist Bioscience Corporation is an Equal Opportunity Employer.
Compensation
- San Francisco Bay Area Pay Range
Company info
- At Twist Bioscience, we work in service of people who are changing the world for the better.
- In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
- We are seeking an experienced and hands-on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives.
This listing is sourced directly from Twist Bioscience's careers page and normalized into a canonical job model.