Remix Therapeutics

Senior Medical Director, Clinical Development

Watertown, MA · Director

Sponsorship not specified$230k-$330kDetected 33 days ago

GCPICD-10Clinical TrialsFDA RegulatoryPharmacovigilanceLeadershipCommunicationCollaborationBiostatisticsRegulatory Affairs

About the role

This role is for a clinician ready to take on real medical ownership and help shape how REM-422 and future programs are developed.
Reporting directly to the Chief Medical Officer at our Watertown, MA headquarters, you will work alongside senior leadership at a pivotal moment in the company's clinical trajectory, with direct visibility into how key development decisions get made.
You will be a core contributor across a small, high-caliber cross-functional team where your judgment matters from day one.

Author and revise clinical documents including protocol synopses, IB sections, ICFs, and CSR narratives
Support FDA and other agency meeting preparation
Collaborate with Clinical Operations on site selection, patient recruitment strategies, and trial execution
Partner with KOLs, CROs, and investigators
REM-422 is our lead program, currently in clinical evaluation for ACC and AML/HR-MDS, and it is at a critical inflection point.
Remix is building the team to bring this novel molecule forward for patients.

5+ years of oncology clinical development experience within a biotech or pharmaceutical organization
Working knowledge of ICH/GCP guidelines and FDA regulatory requirements
Strong scientific acumen with ability to engage deeply with translational data and biomarker-driven programs
Experience with rare solid tumors, ACC, or head and neck oncology
Experience on biomarker-heavy or genomically-selected programs
Familiarity with RNA or spliceosome biology
MD or equivalent medical degree
Hands-on experience as a medical monitor or clinical study physician, including SAE review and site oversight
Familiarity with early-phase (Phase 1/1b) oncology trial design and execution
Excellent written and verbal communication; able to author clinical documents and synthesize complex data for varied audiences
Exposure to hematologic malignancies (AML, MDS)

This range reflects the expected base salary for this position, plus bonus, equity, and benefits as applicable.
Actual salaries may vary based on factors, such as skill, experience, and qualification for the role.
$230,000-$ 330,000 USD

Clinical Trial Execution & Medical Monitoring
Serve as physician lead and medical monitor for REM-422 clinical studies, with direct accountability for patient safety, protocol adherence, and scientific and ethical rigor
Respond to site medical queries, review eligibility exceptions, and support investigators on protocol requirements and deviation management
contribute medical sections to regulatory filings and briefing documents
provide medical input on vendor deliverables, data collection tools, and medical coding

We are seeking someone with 5+ years of industry experience in oncology drug development and looking to grow as Remix scales.
At Remix Therapeutics, we intend to change that.
We are a clinical-stage biopharmaceutical company that has pioneered a new class of small molecule medicines targeting the RNA splicing machinery - correcting the disease-causing errors that drive ACC and other serious conditions at their source.

This listing is sourced directly from Remix Therapeutics's careers page and normalized into a canonical job model.