Novartis
Principal Scientist I/II, Oligonucleotide Chemistry & Innovation
Cambridge (USA) · Principal
Sponsorship not specified$109k-$202kDetected 67 days ago
ResearchAnimal StudiesCommunicationCollaborationMentoring
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odds of building a lasting career here
57Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds (Level III)83
Fits your clock70
Sponsors, but it's cap-subject — you still face the weighted lottery (~45% per draw at Level III). Good if you win; have a cap-exempt backup on your list.
Lottery odds assume a STEM candidate.
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Files H-1B transfers
1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.
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About the role
- Mentor scientists and enhance laboratory workflows to improve efficiency, quality, and innovation.
- Deep expertise in solid-phase oligonucleotide synthesis, deprotection, purification, and characterization.
Responsibilities
- Lead synthesis, purification, characterization, and analysis of chemically modified oligonucleotides and conjugates.
- Design and optimize novel oligonucleotide chemistries through structure-activity relationship studies.
- Develop and implement robust synthetic routes for preclinical RNA therapeutic candidates.
- Drive cross-functional collaboration to advance oligonucleotide therapeutic programs from discovery through preclinical stages.
- Establish and maintain standard operating procedures supporting reproducible oligonucleotide manufacturing processes.
- Operate, troubleshoot, and maintain critical analytical and synthesis instrumentation, including high performance liquid chromatography and liquid chromatography mass spectrometry.
- Proven experience developing and optimizing novel oligonucleotide chemistries and conjugates.
- We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
- USA Relocation Support:
Requirements
- At least five years of experience synthesizing therapeutic oligonucleotides in an industry or research setting.
- Strong knowledge of phosphoramidite chemistry and modern synthetic chemistry techniques.
- Excellent collaboration and communication skills with the ability to work across multidisciplinary teams.
Compensation
- In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
- Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.
- US: 108,500.00 - 201,500.00 USD Annual The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
Benefits
- Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable.
Company info
- Rewards At Novartis, we're committed to reimagining medicine together - and rewarding the people who make it happen.
- The rewards of being part of our team go far beyond base pay and incentives.
Equal opportunity
- EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers.
- Equal Opportunity Employers.
- Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
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This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.