Prime Medicine

Prime Medicine

Medical Director, Clinical Development

Cambridge, MA · Director · Full-time

Sponsorship not specified$272k-$302kDetected 34 days ago
Clinical TrialsClinical ResearchFDA RegulatoryCRISPRResearchCommunicationCollaborationGxPRegulatory Affairs

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odds of building a lasting career here

59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

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H-1B wage level

the lottery is wage-weighted — each level is one more entry

Level IV · 4×
Level I$85,5501 entry
Level II$109,5332 entries
Level III$133,4943 entries
Level IV$157,4774 entries

This range already reaches Level IV — the maximum four lottery entries.

DOL prevailing wage, 2026-27 wage year · Medical Scientists, Except Epidemiologists (19-1042) · Boston-Cambridge-Newton, MA-NH. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.

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About the role

  • Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients.
  • Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung.
  • For more information, please visit www.primemedicine.com.

Responsibilities

  • In collaboration with research, clinical sciences, regulatory affairs and clinical operations, develop a clinical trials strategy for the efficient and safe introduction of Prime gene editing therapeutics into human study participants, through in-human proof-of-concept.
  • Support Prime Medicine regulatory interactions both in the formulation of regulatory documents and in face-to-face discussions with regulators
  • Collaborate with pre-clinical research to implement a translational biomarkers program for all clinical trials, and analyze translational data from Prime Medicine's trials.
  • They will interact broadly across the organization with research and with regulatory affairs in order to implement Prime's strategies across one or more therapeutic areas.

Requirements

  • M.D. or equivalent degree, preferably M.D.-PhD
  • Minimum 3+ years industry or equivalent academic experience, either overseeing clinical trials or performing relevant research
  • Ability to work in a heavily matrixed, cross-functional environment
  • Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
  • Travel to investigator sites, regulatory meetings and conferences will be required.
  • Must be able to travel up to 25%.
  • Track record of scientific and medical excellence
  • Rigorous understanding of core scientific concepts in gene therapy, genetics and immunology
  • Specialization in Pulmonology or Hepatology preferred, but not required. Broad medical knowledge and facility with novel medical concepts is required.
  • Basic understanding of Good Clinical Practice
  • Facility and comfort with standard statistical methodologies and analytical tools
  • Strong communication skills, with demonstrated experience composing scientific publications and delivering oral presentations.
  • The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).
  • Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits-including medical, dental, vision, life insurance, a 401(k) match, and equity programs-along with generous paid time off, wellness days, and company-wide recharge breaks.

Nice to have

  • Specialization in Pulmonology or Hepatology preferred, but not required.

Compensation

  • $272,000 - $302,000 USD

Benefits

  • With support from clinical sciences and medical writing, conceptualize and author clinical trials protocols, including observational and all interventional trials from phase I - IV
  • Serve as medical monitor, responsible for interfacing with site investigators, overseeing patient safety and analyzing data from clinical trials
  • Attend scientific and medical conferences as needed, to support presentation of Prime Medicine data and/or acquire state-of-the-art information in a relevant therapeutic field.

Company info

  • We are seeking a physician-scientist with an interest and/or background in gene therapy to lead Prime Medicine's programs from pre-clinical development into the clinic.
  • The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies.

Equal opportunity

  • Prime Medicine is proud to be an equal opportunity employer.
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This listing is sourced directly from Prime Medicine's careers page and normalized into a canonical job model.