Capable

Capable

Hardware Engineer, Peptide Synthesis Automation

San Francisco

Sponsorship not specified$130k-$190kDetected 26 days ago
RoboticsMechanical DesignElectrical EngineeringHardware DesignRF EngineeringControlsResearchMass SpectrometryProblem SolvingMentoring

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odds of building a lasting career here

37Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

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About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Design and develop automated peptide synthesis systems for high-throughput, reliable solid-phase peptide synthesis, encompassing reagent delivery, resin handling, deprotection, coupling, washing, cleavage interface, and process monitoring.
  • Develop advanced reaction modules for SPPS, such as resin cartridges, packed-bed reactors, agitation/mixing solutions, temperature management, microwave or thermal integration, inline sensing, and reproducible reagent contact.
  • Create robust control systems to manage timed reagent addition, flow rate, pressure, temperature, mixing, cycle logic, fault detection, and implement automated recovery procedures for clogs, leaks, pressure excursions, or failed deliveries.
  • Assess and validate hardware performance against key chemical outputs such as crude purity, deletion sequences, incomplete coupling, side products, yield, reproducibility, cycle time, resin swelling, and cleavage efficiency.
  • Collaborate closely with chemists to translate synthesis failure modes into hardware improvements, addressing challenges such as poor mixing, insufficient reagent excess, channeling, dead volume, moisture ingress, valve carryover, slow draining, temperature gradients, or instrument downtime.
  • Develop test protocols and quality acceptance criteria for each subsystem, including dispense accuracy, carryover, leak rate, pressure stability, thermal uniformity, solvent compatibility, and run-to-run reproducibility.
  • Drive efforts towards creating an instrument that enables faster, more reproducible peptide synthesis with minimal manual intervention compared to standard industry workflows.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • You possess the expertise and confidence to take ownership of complex physical systems and are committed to delivering dependable, high-quality performance.
  • You may have a background in mechanical engineering, electrical engineering, chemical engineering, bioengineering, analytical chemistry, automation, robotics, or possess equivalent hands-on experience.
  • You do not need to have experience with every item on this list
  • we value deep expertise in some areas and a willingness to learn in others.

Compensation

  • $130,000-$190,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $130,000-$190,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • ABOUT THE ROLE We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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This listing is sourced directly from Capable's careers page and normalized into a canonical job model.