Sarepta
Scientist-II Developability & Preformulation
Columbus, OH · Mid
No sponsorship$106k-$133kDetected 1 day ago
Data AnalysisCRISPRResearchAnimal StudiesLeadershipCommunicationCollaboration
About the role
- The promise of genetic medicine has arrived, and Sarepta is at the forefront.
- In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
- The Scientist II will also consider route-of-administration factors, such as subcutaneous delivery, during early formulation assessments (e.g., stability and viscosity at high concentrations, potential enabling approaches).
Responsibilities
- Plan and execute formulation experiments to assess and optimize the stability of key intermediates and final products throughout the manufacturing process.
- Support cross-functional teams by providing recommendations on product handling and storage considerations.
- Train and support Research Associates in experimental execution, troubleshooting, and data interpretation.
- Support for Caregivers
- Experience applying Design of Experiments (DoE) principles to formulation development is a plus.
Requirements
- Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering
- Experience with biologics formulation (e.g., mAbs ) is required.
- Experience with AOCs or antibody-drug conjugates (ADCs) formulation is a plus.
- Hands-on experience with protein formulation technologies (e.g., Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AMBR Crossflow, Pendotech 5TFF, Repligen KR2i, etc. ).
- Experience with stability and analytical assays to monitor product quality, including SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, and mass spectrometry.
- Experience with high-concentration formulation challenges (e.g., viscosity mitigation strategies, excipient screening, protein-protein interaction understanding)
- Proficiency in statistical or data analysis tools (e.g., JMP, GraphPad, SigmaPlot ) is a plus.
Compensation
- The targeted salary range for this position is $106,400 - $133,000 per year.
Benefits
- Financial Wellness
Visa & Work Authorization
- Candidates must be authorized to work in the U.S.
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