GH
Staff Scientist-LCMS
Palo Alto, CA · Staff+
Sponsorship not specified$150k-$206kDetected 21 days ago
Patient CareFDA RegulatoryMass SpectrometryCollaboration
About the role
- Company Description Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer.
- Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer.
- For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.
Responsibilities
- Develop and optimize targeted LC-MS methods (MRM/PRM) for small molecules, lipids, and/or peptides
- Design and refine LC gradients to achieve optimal separation, sensitivity, and throughput
- Optimize MS/MS parameters (collision energy, resolution, scan speed, dwell time)
- Establish and implement quantification strategies (internal standards, calibration curves, QC normalization)
- Support method transfe r across instruments and sites
- Document methods and support CLIA/FDA-aligned validation and SOP development
- If you need support, please reach out to Peopleteam@guardanthealth.com
- We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires.
Requirements
- 5+ years of experience in targeted LC-MS method development
- Hands-on expertise with PRM (HRMS)
- Strong understanding of quantitative LC-MS workflows in biological matrices
- Employee may be required to lift routine office supplies and use office equipment.
- A background screening including criminal history is required for this role.
Nice to have
- Experience in lipidomics, proteomics, or clinical assays
- Familiarity with regulated environments (CLIA/FDA/ISO)
- Experience with high-throughput or automated workflows
- Experience with biological specimens.
- Experience with high resolution mass spectrometry
Compensation
- $150,100 - $206,400Other
- $127,585 - $175,440If the role is performed in
- $135,090 - $185,760
Benefits
- This range does not include benefits or, if applicable, bonus, commission, or equity.
- Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.Primary
Equal opportunity
- All your information will be kept confidential according to EEO guidelines.
This listing is sourced directly from GH's careers page and normalized into a canonical job model.