Glyphic Biotechnologies

Glyphic Biotechnologies

Scientist / Senior Scientist, Assay Development (Reagents)

Berkeley, CA · Senior · Full-time

Sponsorship not specified$112k-$162kDetected 60 days ago
Experimental DesignMass SpectrometryCommunicationCollaborationProblem SolvingPublic SpeakingAdaptability

About the role

  • You have experience not just characterizing reagents but qualifying them - setting acceptance criteria, gating go/no-go decisions on incoming lots, and maintaining the provenance records that high-stakes single-molecule runs demand.
  • You are comfortable working at the bench and translating your findings into SOPs, QC protocols, and reagent inventories that the broader Assay Development team can rely on.
  • This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

Responsibilities

  • Lead assay reagent development activities, including formulation, characterization, and optimization, for components used in ProSE single-molecule expansion and library preparation workflows, including enzymes, oligos, beads, and solvents.
  • Characterize reagent performance using design-of-experiments (DOE) approaches, systematically varying formulation conditions, buffer composition, excipients, and process parameters to establish operating bounds and define product specifications.
  • Design and execute experiments to evaluate reagent performance in end-use assay configurations
  • develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes.
  • Design and execute reagent storage stability studies under accelerated and real-time conditions
  • develop stability-indicating assays
  • Build and implement a QC and control framework for platform reagents, including acceptance criteria, lot release protocols, and QC assay development, to support reliable, consistent supply to the Assay team.
  • Develop, qualify, and transfer QC test methods for reagent characterization and lot release, including HPLC, fluorescence-based functional assays, and physical characterization methods
  • set product, process, and incoming material acceptance criteria in collaboration with Assay and cross-functional partners.
  • Design and execute experiments to evaluate reagent performance in end-use assay configurations; develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes.

Requirements

  • Degree in Biochemistry, Chemical Biology, Biophysics, Biomedical Engineering, or an equivalent field
  • PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist)
  • PhD / MS / BS with 2+ / 4+ / 6+ years of relevant experience (Scientist II)
  • with practical experience across the full reagent development cycle including formulation, stability studies, and QC method development.
  • Strong written and verbal communication skills, with the ability to work effectively with colleagues across diverse scientific and technical backgrounds.

Nice to have

  • Background in proteomics reagents, protein modification chemistry, peptide-oligonucleotide conjugates, or single-molecule assay components.
  • Experience with automation platforms for liquid handling (e.g., Hamilton, ThermoFisher, Agilent) and protocol validation on automated workcells.
  • Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
  • Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
  • Treats obstacles as problems to be creatively solved, not reasons something can't be done.
  • Shares early and directly when assumptions change, results are unclear, or timelines are at risk.
  • What you can expect from this role
  • Work environment:

Skills

  • Learn from a diverse team of world-class scientists and engineers
  • Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation

  • Estimated Base Salary $111,725 - $161,900
  • This is the pay range for this position that we reasonably expect to pay.
  • Individual compensation is based on various factors including, experience, education, skillset, and geographic location.

Benefits

  • Employee Stock Option Plan
  • 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
  • Employer Retirement Contributions to 401(k)
  • Generous Paid Time Off
  • Paid Maternity and Paternity Leave
  • Health & Wellbeing Program
  • To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

Equal opportunity

  • We are an Equal Opportunity Employer.
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