Generate Biomedicines

Generate Biomedicines

Senior Director, Protein Analytics & Biophysics

Somerville, MA · Director

Sponsorship not specified$210k-$290kDetected 137 days ago
Machine LearningStatisticsA/B TestingRecruitingPharmacy PracticeMolecular BiologyMass SpectrometryAnimal StudiesLeadershipCommunicationCollaborationMentoring

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odds of building a lasting career here

56Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role72
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

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Files H-1B transfers

2 transfer filings in the last year, covering 2 workers. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

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About the role

  • Define the next generation of biophysical, biochemical, developability, and protein-protein interaction measurement capabilities for protein therapeutics, with a particular focus on miniaturized, pooled, high-throughput, and nanoscale approaches.
  • Establish data standards, quality expectations, assay controls, and analytical frameworks that allow high-throughput measurements to be used confidently for model training, candidate triage, and program decision-making.
  • Ensure the function generates high-quality, decision-enabling data across Discovery, Candidate Selection, and early Development, including developability, stability, specificity, affinity, kinetics, and manufacturability-relevant attributes.

Responsibilities

  • Lead the continued evolution of conventional analytical and interaction workflows, including HPLC/UPLC, LC/MS, electrophoretic, thermal stability, light scattering, plate-based, and biosensor-based platforms, ensuring rigor, reproducibility, and decision relevance.
  • Build a strategy that connects conventional analytical and biosensor technologies with emerging pooled or massively multiplexed approaches, enabling Generate to measure protein attributes at scales that match the output of generative design.
  • Identify, evaluate, and implement external and internal technologies that can unlock smaller sample volumes, richer attribute profiles, higher throughput, improved sensitivity, or new classes of protein interaction and developability data.
  • Drive operational excellence across the function, including prioritization, resource planning, milestone delivery, metrics, continuous improvement, and clear communication of tradeoffs.
  • Represent the function with executive stakeholders and external partners, translating complex scientific strategy into clear, compelling, and actionable plans.
  • Lead as a strong people leader and culture builder who develops trust, accountability, scientific ambition, and collaboration across a multidisciplinary organization.
  • Build, coach, and develop a high-performing team of managers, senior scientists, and technical experts, creating clear growth paths and succession strength within the function.

Requirements

  • Strong understanding of protein-protein interaction measurement, including affinity, kinetics, specificity, cross-reactivity, epitope/binning, avidity, and context-dependent binding behavior.

Compensation

  • The base salary range provided reflects our current estimate of what we anticipate paying for this position.
  • Your actual base salary will be based on several factors, including job-related skills, experience, internal equity, relevant education or training, and market dynamics.
  • In addition, you will be eligible for an annual bonus, equity compensation, and a competitive benefits package.
  • Per Year Salary Range
  • $210,000 - $290,000 USD

Benefits

  • Set and drive the multi-year scientific and organizational vision for Protein Analytics & Biophysics, aligning functional strategy with Generate's platform, portfolio, and company priorities.

Company info

  • Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities.
  • We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
  • Partner effectively across functions to advance shared company goals.

Visa & Work Authorization

  • al employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status
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This listing is sourced directly from Generate Biomedicines's careers page and normalized into a canonical job model.