Madrigal Pharmaceuticals
Director, Clinical Scientist
PA - Conshohocken - Office, USA · Director · Full-time
Sponsorship not specified$215k-$264kDetected 27 days ago
GCPProject ManagementCompensationClinical TrialsClinical ResearchFDA RegulatoryResearchExperimental DesignLeadershipCommunicationCollaborationBiostatistics
About the role
- Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
- Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3).
- An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Responsibilities
- Providing strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestone, the Director, Clinical Scientist will:
- Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria.
- Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions.
- Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support.
Requirements
- Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required
- 5+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry.
- Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master's with relevant experience may be considered.
Nice to have
- Prior experience in liver disease, metabolic disorders, or MASH/NASH strongly preferred.
- Preferred Attributes:
- Experience supporting regulatory interactions or submissions is a plus.
Compensation
- Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity.
Benefits
- Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity.
- Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team.
- Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations.
- Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity.
Company info
- Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality.
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