Novartis

Novartis

Principal Scientist - Formulation

Cambridge (USA) · Principal

Sponsorship not specifiedDetected 12 days ago
PythonMachine LearningData AnalysisInventory ManagementClinical TrialsCRISPRMolecular BiologyResearchExperimental DesignMass SpectrometryLeadershipCommunicationCollaborationProblem SolvingMentoringPublic Speaking

About the role

  • You will work closely with a team of more than 10 associates, driving scientific excellence while fostering a culture of collaboration, integrity, and innovation aligned with Novartis values.
  • You will play a key role in shaping formulation strategies during early-stage development and supporting candidate selection by identifying developability risks.
  • This position offers broad exposure to diverse biologics modalities and opportunities to contribute both experimentally and strategically.

Responsibilities

  • Design and execute formulation screening strategies for large-molecule therapeutics, with emphasis on mAbs and related biologic modalities
  • Lead studies to identify stable formulations and communicate results to cross-functional R&D teams
  • Manage team resources, timelines, and deliverables with a strong customer-focused mindset
  • Partner with CMC teams to advance clinical candidates, finalize clinical formulations, and support drug product process development
  • Develop stabilization strategies for liquid, frozen, and lyophilized drug product formats for clinical development
  • Work with automation teams to implement high-throughput formulation screening and physicochemical characterization across discovery, optimization, and early development
  • Operate analytical instrumentation, analyze data, maintain ELN documentation, and author technical reports
  • Proven experience leading, coaching, and developing scientific teams
  • Strong background in developing strategies for formulations for large-molecule therapeutics, with understanding of early-stage development workflows
  • Familiarity with DoE tools (e.g., JMP) for high-throughput experimental design

Requirements

  • PhD in biochemistry, biotechnology, chemistry, or a related field with 2+ years of relevant industry experience
  • Hands-on expertise in protein formulations and assessment of biophysical of the molecule (e.g., DLS, Viscosity, Thermal and colloidal stability)
  • Experience designing and executing preformulation studies and interpreting stability-indicating assays (e.g., SEC, CE, charge variants, MS)
  • Demonstrated problem-solving skills, scientific curiosity, and ability to work independently
  • Knowledge of viral vector-based gene therapy (AAV, LVV) formulation and characterization
  • Experience working with automated liquid handling systems

Compensation

  • $108,500.00 - $201,500.00
  • The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and between $119,700 and $222,300 per year for Principal Scientist II.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.
  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

Benefits

  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
  • US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
  • In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • To learn more about the culture, rewards and benefits we offer our people click here.

Equal opportunity

  • The Novartis Group of Companies are Equal Opportunity Employers.
  • Accessibility and reasonable accommodations
  • The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
  • Please include the job requisition number in your message.
Apply directly at Novartis →Create a free account for alerts like thisView Novartis immigration profile

This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.