Nurix Therapeutics

Nurix Therapeutics

Associate Director, Chemical Engineering

Brisbane, California, United States · Director

Sponsorship not specified$190k-$217kDetected 17 days ago
Supply ChainProcess ImprovementPatient CareGMPFDA RegulatoryLeadershipCommunicationProblem SolvingMentoring

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odds of building a lasting career here

59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

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Employer immigration record

from this employer's Department of Labor filings

Files H-1B transfers

2 transfer filings in the last year, covering 2 workers. Median labor-condition decision: 8 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.
  • The position will report to the Director, Chemical Development.

Responsibilities

  • Provide engineering leadership to design, develop and optimize scalable routes for small-molecule DS manufacturing, including demonstrated knowledge in unit operation design, process modeling, process equipment selection and scale-up methodologies.
  • Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure equipment trains are properly qualified, maintained and operating at optimal performance to support Nurix manufacturing operations.
  • Lead technology transfer to CDMOs including scale-up and demonstration of new chemical processes in development and commercial equipment.
  • Partner within Nurix CMC to drive process understanding (critical process parameters, critical quality attributes, control strategy) using engineering principles, DoE and QbD concepts.
  • Provide regular Person-In-Plant support for DS manufacturing and ongoing performance monitoring of key facility and operational KPIs across manufacturing sites, including schedule adherence, batch performance, deviation trends, and inspection readiness.
  • Define and drive the long‑term engineering strategy for bexobrutideg DS, including process robustness, lifecycle management, and cost‑of‑goods optimization.
  • Manage and provide technical mentorship of scientists and engineers.
  • Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases.
  • Nurix is seeking an experienced, independent, and highly motivated individual who will be accountable for end‑to‑end chemical engineering support of bexobrutideg (NX-5948) drug substance (DS) from late‑stage development through commercial launch, including oversight of external manufacturing sites.
  • The Associate Director, Chemical Engineering will work closely with the CMC team and colleagues in cross-functional departments to provide scientific, technical, and hands-on leadership and oversight of facility and equipment operations at Contract Development Manufacturing Organizations (CDMOs) to support bexobrutideg drug substance manufacturing process optimization and scale-up.

Requirements

  • Ph.D. in chemical engineering, or related field with at least 5 years (M.S. with 10 years or B.S. with 15 years) of industrial, late-phase, small-molecule drug substance development experience
  • Extensive knowledge and experience in GMP drug substance manufacturing, characterization, process development, equipment evaluation/selection, scale up and process validation.
  • Knowledge of solid‑state, polymorphism, and crystallization principles relevant to small‑molecule drug substance.
  • Extensive third-party drug substance CDMO management experience including tech transfer activities, QbD and DoE studies, clinical supply production, registration batch production and commercial launch activities.
  • In-depth knowledge of relevant cGMP, ICH, FDA and EMA guidelines.
  • Proven track record of effective internal and external collaboration.
  • Ability to travel up to 25% of their time.

Compensation

  • $189,800 - $216,700

Benefits

  • Author and review CMC sections of regulatory filings including INDs/IMPD, and NDA/MAA, including responses to Health Authority queries.
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This listing is sourced directly from Nurix Therapeutics's careers page and normalized into a canonical job model.