Novartis

Novartis

ADME Scientist, Antibody–Oligonucleotide Conjugates (Principal Scientist I/II)

San Diego · Principal

Sponsorship not specifiedDetected 72 days ago
Clinical TrialsClinical ResearchPharmacologyPatient CareMolecular BiologyResearchMass SpectrometryAnimal StudiesCollaborationOrganizational Skills

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Cap-exempt (no lottery)0
Sponsors this role90
Entry-level history0
PERM / green-card track0
Lottery odds40
Fits your clock70

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About the role

  • Apply immunoprecipitation and affinity-capture methods to enrich antibody-conjugated species from plasma, tissue, and cellular samples.
  • Use LC-MS/MS and high-resolution MS approaches to assess conjugate integrity, stability, biotransformation, and tissue biodistribution.
  • Novartis is seeking a highly motivated ADME scientist for a laboratory-based role supporting the discovery and early development of antibody-oligonucleotide conjugates, including antibody-siRNA and antibody-PMO modalities.

Responsibilities

  • Develop and execute fit-for-purpose ADME and biotransformation workflows for antibody-oligonucleotide conjugates in biological matrices.
  • Independently design, troubleshoot, and interpret in vitro and in vivo studies linking laboratory findings to PK/PD and candidate selection decisions.
  • Experience developing or executing LC-MS/MS or HRMS-based methods to characterize metabolic stability, biotransformation, and molecular fate of antibody-oligonucleotide conjugates.
  • Strong organizational skills, attention to detail, scientific rigor, and ability to manage multiple studies and priorities.
  • We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Requirements

  • Demonstrated hands-on laboratory experience with immunoprecipitation, affinity capture, biological sample preparation, and LC-MS/MS or HRMS-based workflows is required.
  • Strong understanding of ADME principles and their application to new modalities, including oligonucleotides, antibody conjugates, biologics, or other complex therapeutics.
  • Experience with antibody-oligonucleotide conjugates, antibody-siRNA conjugates, antibody-drug conjugates, therapeutic proteins, or other targeted delivery platforms.
  • Experience with biological sample preparation from plasma, tissue homogenates, cells, or subcellular fractions.
  • Experience with laboratory automation, liquid handling, assay miniaturization, or higher-throughput sample preparation.
  • The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered.
  • Ability to work effectively in a cross-functional, matrixed project environment and communicate complex scientific data clearly to project teams.
  • Knowledge of oligonucleotide metabolism, nuclease-mediated degradation, linker stability, conjugate heterogeneity, and tissue distribution challenges.
  • Familiarity with ligand-binding assays, hybridization-based assays, ligand capture LC-MS workflows, proteomics, or intact/protein-level mass spectrometry.

Skills

  • Chemistry, Clinical Pharmacology, Clinical Research, Medical Research, Patient Care, Physiology, Simulation Software, Translational Medicine

Compensation

  • $108,500 and $201,500 per year.
  • $119,700 and $222,300 per year.
  • The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.
  • Novartis may change the published salary range based on company and market factors.
  • Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.
  • $108,500.00 - $201,500.00

Benefits

  • US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.
  • In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.
  • To learn more about the culture, rewards and benefits we offer our people click here.

Equal opportunity

  • The Novartis Group of Companies are Equal Opportunity Employers.
  • The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities.
  • EEO Statement:
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This listing is sourced directly from Novartis's careers page and normalized into a canonical job model.