Cartography Biosciences

Cartography Biosciences

Associate Director / Director, Protein Sciences

South San Francisco, CA · Director

Sponsorship not specifiedDetected 11 days ago
PythonMachine LearningPharmacologyGMPBioinformaticsResearchProtein AnalysisAnimal StudiesLeadership

About the role

  • CBI-1214 entered the clinic in early 2026 and is currently enrolling and treating patients in a phase 1 trial.
  • This is a hands-on, hybrid role based onsite in South San Francisco.
  • The role balances hands-on internal work with external program management, and we expect the scope to evolve as the team and Cartography's CMC organization grow.

Responsibilities

  • External Manufacturing & CDMO Partnerships Serve as the technical lead to our external manufacturing partners across cell line development, upstream and downstream process development, analytical method development, and GMP drug substance and drug product for gene to IND CMC programs Ensure external programs deliver drug product to specification, on time, and on budget.
  • Support ongoing process development for clinical stage programs, including early high-concentration formulation development to enable subcutaneous dosing.
  • Protein Expression Build recombinant antibody expression, in house and through external CROs, spanning 96-well / deep-well high-throughput transient screening and mL-to-L bench-scale transient mammalian production (Expi293, ExpiCHO, transient CHO) to support research and in vivo studies (mouse efficacy / PK and non-GLP NHP).
  • Optimize transient production of multi-chain bispecific and multispecific assemblies (knob-into-hole heterodimers, VHH-containing trispecifics), including plasmid chain-ratio tuning to maximize correctly assembled product.
  • Increase expression and screening throughput to support AI/ML-driven design, build, and test cycles.
  • Develop format-specific strategies that resolve bispecific product-related species (heavy-chain homodimer, half-antibody, and light-chain-mispaired variants) from the correctly paired heterodimer.
  • Operate AKTA-scale chromatography and high-throughput magnetic-bead purification (KingFisher or equivalent) to support candidate triage and research supply.
  • Deliver low-endotoxin, high-monomer, clinically representative material meeting in vivo dosing specifications for pharmacology and toxicology studies.
  • Analytical & Developability Characterization Manage and improve internal developability and characterization capabilities (e.g., analytical SEC, HIC, DSF, CE-SDS (reduced and non-reduced), and DLS).
  • Own developability triage and candidate ranking, and feed results into lead selection with Antibody Engineering colleagues.

Requirements

  • Familiarity supporting Module 3 (CMC) of IND filings.
  • Experience with bispecific antibodies or other complex antibody formats (e.g. knob-into-hole, multispecific, VHH / single-domain fusions).
  • Experience with mammalian expression and cell line development, including transient systems (Expi293, ExpiCHO) and stable cell line development.
  • Working knowledge of core biophysical and analytical methods (analytical SEC, HIC, DSF, CE-SDS, DLS).

Nice to have

  • Experience with liquid-handling automation and high-throughput antibody purification and characterization.
  • High-concentration (greater than 100 mg/mL) subcutaneous formulation development and management of outsourced formulation programs.
  • Track record advancing a biologic through IND-enabling CMC.
  • Knowledge of T-cell engaging antibody platforms (TCEs, bispecifics, multispecifics) and a background in oncology or immuno-oncology.
  • Proficiency in a programming language (e.g. Python) and experience with AI-assisted or agentic coding tools.
  • Protein A capture with orthogonal polishing by ion exchange, hydrophobic interaction, and mixed-mode chromatography, plus analytical and preparative size-exclusion.
  • Confirm correct chain pairing and quantify product-related species (homodimer, half-antibody, mispaired variants) for bispecific and multispecific molecules.
  • Team Leadership & Cross-Functional Work Mentor and grow a small internal protein sciences team and set the day-to-day practices and priorities for the function.

Company info

  • We are looking for an Associate Director or Director of Protein Sciences to lead protein sciences and external manufacturing for our programs as they advance toward the clinic.
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