Iambic Therapeutics

Principal Scientist, Medicinal Chemistry

San Diego HQ · Principal

Sponsorship not specifiedDetected 98 days ago

Machine LearningA/B TestingClinical TrialsPharmacologyResearchLeadershipCommunicationProblem SolvingTime Management

About the role

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery.
Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting.
The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.

Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME using multivariant SAR analysis and hypothesis driven design principles.
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules

Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years' experience, M.S. with 12+ years' experience or Ph.D. with 8+ years' experience.
Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS)
Ability to integrate multiple R&D disciplines into a successful strategic project plan
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
Proven track record of success in advancing programs from leads to advanced candidates.
Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Creative problem solving and management of relationships with several stakeholders within and beyond the company

We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team.

We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

This listing is sourced directly from Iambic Therapeutics's careers page and normalized into a canonical job model.