Neurocrine
Scientific Director, Computational Chemistry
US CA San Diego · Director
Sponsorship not specified$218k-$298kDetected 20 days ago
Machine LearningData AnalysisData ScienceIntellectual PropertyPharmacologyFDA RegulatoryResearchLeadershipCollaborationPublic Speaking
About the role
- Represents Computational Chemistry across Research and Development functions and seamlessly integrates internal and external technologies, collaborations, and resources to advance Neurocrine's drug discovery strategy.
- Serves as a mentor and scientific leader, fostering the development of junior scientists and promoting excellence within the computational chemistry function. _
- Your Contributions (include, but are not limited to):
Responsibilities
- Develops, implements, and enforces scientifically sound computational chemistry strategies that support drug discovery programs from target validation through lead optimization and candidate selection
- Leads the application of molecular modeling, structure-based drug design, ligand-based design, and AI/ML approaches to enable compound design and optimization
- Evaluates, interprets, and communicates computational results, proactively providing strategic direction to project teams and senior management on compound design and program progression
- Establishes and oversees computational workflows, best practices, and reproducible methods to support high-quality and efficient research
Requirements
- Bachelors in chemistry or related field AND 12+ years of experience applying computational chemistry in a drug discovery setting OR
- Masters in computational chemistry or related field AND 10+ years of experience applying computational chemistry in a drug discovery setting OR
- PhD in computational chemistry, organic chemistry or a related field AND 8+ years of experience applying computational chemistry in a drug discovery setting
- Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency.
- Experience integrating computational chemistry into multidisciplinary drug discovery teams
- Strong track record of scientific achievement, including publications and/or patents
- Experience with AI/ML approaches in drug discovery, including predictive modeling and generative design
- Familiarity with CNS drug discovery or neuroscience-focused research
- Experience working with cloud computing and high-performance computing environments including programming computational workflows in Knime or equivalent.
Compensation
- The annual base salary we reasonably expect to pay is $218,200.00-$298,000.00.
Company info
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- About the Role:
- Develops and leads innovative computational strategies that accelerate drug discovery across a Research and Development portfolio from early discovery through clinical candidate nomination. Integrates computational approaches including molecular modeling, cheminformatics, molecular dynamics, free energy perturbation, and AI/ML-driven drug design to support data-driven decision-making and the optimization of therapeutics across multiple modalities, including small molecules and biologics. Working within multidisciplinary teams of medicinal chemists, structural biologists, pharmacologists, data scientists, and ADME/Tox representatives, provides molecular-level insight and computational expertise to inform compound design, potency and selectivity optimization, and de-risk design hypotheses. Represents Computational Chemistry across Research and Development functions and seamlessly integrates internal and external technologies, collaborations, and resources to advance Neurocrine's drug discovery strategy. Supports senior leadership through long-term strategic planning, technology innovation, resource management, and the continuous evolution of computational capabilities to ensure effective achievement of scientific and operational objectives. Serves as a mentor and scientific leader, fostering the development of junior scientists and promoting excellence within the computational chemistry function. _
- Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs.
- We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders.
- The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.
- For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions.
- We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science.
- For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. ( *in collaboration with AbbVie )
- to relieve suffering for people with great needs.
Apply directly at Neurocrine →Create a free account for alerts like thisView Neurocrine immigration profile
This listing is sourced directly from Neurocrine's careers page and normalized into a canonical job model.