Bicycle Therapeutics

Bicycle Therapeutics

Senior Director, Biostatistics

Lexington, MA, United States · Director · Full-time

Sponsorship not specified$235k-$295kDetected 12 days ago
GCPStatisticsClinical TrialsClinical ResearchFDA RegulatorySASResearchExperimental DesignLeadershipCollaborationProblem SolvingMentoringBiostatisticsRegulatory Affairs

About the role

  • Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry.
  • This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.
  • Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA.

Responsibilities

  • Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics.
  • You guide the statistical and quantitative strategy across multiple functions, shaping the company's approach to clinical study design and data analysis.
  • You shape the cross-functional direction of clinical programs, participating in key strategic decisions on study design and data interpretation.
  • You develop future organisational leaders, providing coaching to senior statistical professionals and ensuring robust succession planning for your function.
  • You coach senior leaders and statistical experts, actively engaging in succession planning to build our future leadership pipeline.
  • We recognize that diverse and inclusive teams build a stronger and more innovative company.

Compensation

  • $235,000 - $295,000
  • We have shared the expected recruitment base pay range for this full-time position based on the anticipated location.
  • The actual base pay will depend on several factors unique to each candidate, including skills, qualifications, experience, and the actual location of the role.
  • At Bicycle, base pay is just one component of the total reward package.
  • This role is also eligible for Bicycle's discretionary annual bonus program (or sales incentive program), its comprehensive health and retirement benefit programs, and equity grants.

Benefits

  • Flexible working environment
  • Competitive reward including annual company bonus
  • Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
  • Health and Dependent Care Flexible Spending Accounts
  • 401(k) plan with a 4% Company match and immediate vesting
  • Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
  • Competitive Family Leave Policy
  • During the hiring process, your Bicycle recruiter can share more about the Company's total reward package.

Company info

  • We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
  • We are Dedicated to our Mission. You can't change the world if you don't have determination.
  • We are One Team. We only succeed when we work together.
  • You will lead, coach, and mentor your team of biostatisticians, investing in their professional growth and fostering a culture of high performance and psychological safety.
  • You will set clear goals and strategic priorities for the biostatistics function, ensuring its work is directly aligned with departmental and organizational objectives.
  • You will champion the Bicycle Values in all that you do, acting as a role model and embedding a culture of collaboration, accountability, and innovation within your team.
  • Serve as the program-level biostatistical lead for key development assets, providing strategic input and quantitative expertise to shape the clinical development plan.
  • Collaborate with senior leaders in Medical, Clinical Research, and Regulatory Affairs to address critical questions and support data-driven clinical decision-making.
  • Represent the biostatistics function in all regulatory interactions, including providing statistical expertise for meetings and authoring key sections of regulatory documents.
  • Provide senior oversight for all study-level biostatistical activities, including work conducted by vendors, to ensure the highest standards of quality and timeliness.
  • Apply advanced statistical methods, including modeling and simulation, to solve challenging issues in study design, analysis, and interpretation.
  • Provide expert review and approval for key statistical documents, including protocols and Statistical Analysis Plans (SAPs), ensuring they are fit for purpose.
  • Extensive experience and a record of senior leadership in biostatistics within the biopharmaceutical industry, with a deep focus on oncology clinical trials.
  • Proven experience in people management and leading high-performing technical teams.
  • Demonstrated ability to develop and execute the statistical strategy for clinical development programs and translate complex data into clear, impactful insights.
  • Authoritative knowledge of advanced statistical methods, regulatory guidelines (GCP), and their application to all phases of clinical development.
  • Proficiency with statistical programming languages (e.g., R, SAS) and a deep understanding of simulation and modeling techniques.
  • You lead the organisation confidently through major data readouts and regulatory submissions, providing clear direction and fostering enterprise-wide alignment.
  • Dedicated to our Mission

Equal opportunity

  • Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve.
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This listing is sourced directly from Bicycle Therapeutics's careers page and normalized into a canonical job model.