Capable

Capable

Scientist / Senior Scientist, Medicinal Chemistry

San Francisco · Senior

Sponsorship not specified$145k-$220kDetected 26 days ago
RF EngineeringMass SpectrometryAnimal StudiesMentoring

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odds of building a lasting career here

37Unrated
Cap-exempt (no lottery)0
Sponsors this role0
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

No strong sponsorship signal in the public record yet. In the full product we resolve the exact legal entity and show its filing history with a confidence score — treat as unverified until then.

Lottery odds assume a STEM candidate.

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About the role

  • We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
  • Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.

Responsibilities

  • Lead medicinal chemistry design and synthesis across small-molecule, peptide, and peptide-adjacent programs, from target compound selection through synthesis, purification, characterization, and handoff for biological testing.
  • Design and execute synthetic routes using solid-phase and solution-phase workflows, including functional group transformations, coupling chemistry, protecting group strategies, late-stage diversification, cleavage/deprotection where relevant, purification, and analytical characterization.
  • Learn, operate, and help maintain key chemistry instrumentation, including HPLC/prep HPLC, LC-MS, microwave-assisted synthesis systems, and related analytical or purification platforms.
  • Interpret SAR, in vitro, and in vivo data to design next-round compounds, using potency, selectivity, stability, exposure, tolerability, and efficacy data to guide priorities.
  • You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.
  • We value speed and rigor, coupled with excitement, drive, and a strong work ethic.
  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

Requirements

  • You have 5+ years of hands-on industry experience in medicinal or synthetic organic chemistry.
  • Peptide experience is helpful, but not required.
  • You have strong experimental judgment, deep troubleshooting ability, and a high bar for execution.
  • You are proactive and reliable when issues arise.

Compensation

  • $145,000-$220,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.

Benefits

  • $145,000-$220,000 salary, plus equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
  • $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
  • You will also have access to HSA, FSA, and 401K plans.
  • We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.

Company info

  • ABOUT THE ROLE We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
  • Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.
  • If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Visa & Work Authorization

  • We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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