Natera
Director of Bioinformatics and Machine Learning
San Carlos, CA · Director
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DOL prevailing wage, 2026-27 wage year · Data Scientists (15-2051) · San Francisco-Oakland-Fremont, CA. Wage level is derived by USCIS from the offered wage, occupation and worksite; the occupation shown is inferred from the job title.
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About the role
- The ideal candidate is a hands-on scientific leader who sets technical direction and stays close to the work by challenging analyses, reviewing models, and prototyping when needed.
- They combine deep expertise in bioinformatics and machine learning with experience translating research into clinical diagnostics.
Responsibilities
- Own the computational design of research studies, including cohort selection, confounder control, and validation strategies that prevent overfitting and data leakage.
- Partner with molecular biology teams to design experiments that generate data capable of answering the key scientific and clinical questions.
- Serve as the computational subject matter expert for leadership and cross-functional partners, communicating tradeoffs, risks, and recommendations clearly to technical and non-technical audiences.
- Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.
Requirements
- 10+ years of post-PhD experience in industry or academic research, including 5+ years of direct people management leading technical teams of 5 or more scientists.
- PhD in Bioinformatics, Computer Science, Statistics, or a related quantitative field.
- Demonstrated track record of developing and deploying machine learning and statistical models on high-throughput sequencing data.
- Deep understanding of next-generation sequencing (NGS) data and large-scale genomic datasets, including sources of technical bias and batch effects.
- Strong communication skills, with experience influencing scientific direction at a senior level.
Nice to have
- Experience in clinical diagnostics, including contributing to assays that reached analytical or clinical validation.
- Domain expertise in oncology, epigenomics, or cfDNA/liquid biopsy.
- This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire.
- 401(k) with company match
- Compensation Range
- When you join Natera, you'll work hard and grow quickly.
- We also offer a generous employee referral program!
- For more information, visit www.natera.com.
Compensation
- $228,600 - $285,800 USD
Benefits
- Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
- Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
- Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
- Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
Company info
- Natera's mission is to change the management of disease worldwide by using information from a simple blood draw to detect disease early and proactively inform treatment.
- We are seeking a Director of Bioinformatics and Machine Learning to lead technology and biomarker research for our cancer early detection programs.
- This leader will head a team of bioinformatics and machine learning scientists developing the foundation of our next generation of cell-free DNA (cfDNA) assays across multi-cancer early detection (MCED), tissue-free molecular residual disease (tfMRD), and single-cancer screening.
- We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives.
Equal opportunity
- Equal Opportunity Employer.
This listing is sourced directly from Natera's careers page and normalized into a canonical job model.