Shasqi

Principal Scientist, ADME/PK

United States · Principal

No sponsorship$150k-$180kDetected 62 days ago

MATLABPharmacologyAnimal StudiesLeadershipCommunicationCollaboration

About the role

You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment.
We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting.

Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs.
Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure.
Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development.
Collaborate with bioanalytical assay development team to support assay development.
Build and apply PK/PD and mechanistic models to predict human dosing and scheduling.
Partner with toxicology and regulatory teams to support IND-enabling studies.
Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment.
Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it.
Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities.
Our lead asset will be entering the clinic in early 2027.

4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs.
Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics).
Demonstrated experience with QSP and PK/PD modeling.
Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar).
Must be authorized to work in the United States.

Experience with pre-targeting approaches, multi-component therapeutics, or bioorthogonal chemistry systems.
Familiarity with click chemistry reactions (e.g., tetrazine-TCO) in biological systems.
Background in oncology, targeted therapeutics, or drug delivery platforms.
Experience with imaging-based biodistribution (e.g., PET/SPECT, fluorescence).
Knowledge of regulatory expectations for PK/ADME in IND filings.
Strong publication record and presentation skills.
Core collaboration window: 9:00am-3:00pm Pacific Time.
You are expected to be available during this time for meetings and real-time collaboration.

The anticipated base salary range for this role is $150K-$180K USD
Final compensation will depend on location, experience, skills, education, and internal equity.
Competitive base salary as part of a broader total rewards package.

medical, dental, vision, 401(k) match, short- and long-term disability.
Flexible PTO and a WFH stipend to support remote work.
Final compensation will depend on location, experience, skills, education, and internal equity.

We move fast because speed matters to cancer patients.
We aim to communicate openly and challenge ideas regardless of job title.
We are bold, take risks, and push boundaries being led by science.
Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry.
You can learn more about our company at www.shasqi.com http://www.shasqi.com
At this time, Shasqi is not partnering with external recruiting agencies.
We kindly ask that agencies refrain from contacting us regarding this role.
Shasqi is an Equal Opportunity Employer.
We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.
We are not currently sponsoring visas.

Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.
Equal Opportunity Employer.

This listing is sourced directly from Shasqi's careers page and normalized into a canonical job model.