Manifold Bio

Senior Director, Biotherapeutics

Boston · Director

Sponsorship not specified$240k-$340kDetected 63 days ago

Full-Stack DevelopmentMachine LearningLLMsPharmacologyAnimal StudiesLeadershipPublic Speaking

About the role

Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
Position: Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature our discovery, characterization, and production of shuttled therapeutics.
This is a unique opportunity to shape the future of a cutting-edge biotechnology company while working with a collaborative, innovative team.

Manage and mentor internal protein scientists and protein engineers
Build and focus teams in a capital-efficient manner to support current and future pipeline needs
Foster strong collaborative interactions between biotherapeutics teams and teams supporting AI/ML protein design and screening, oligonucleotide therapeutic discovery, and pharmacology
Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
Engage with consultants, contractors and CROs/CDMOs to efficiently build expertise and capabilities that accelerate program progression
Set and implement strategy for developability assessment and early-stage de-risking
Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match.
The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign.
This role spans discovery and nonclinical development, including bioengineering strategies to generate best-in-class molecules and oversight of external contract manufacturing organizations (CDMOs) to develop processes and manufacture drug product for clinical trials.
As a member of our leadership team, you will contribute to high-level strategy and help build internal resources to support our ambitious growth plans.

Required Experience & Skills
Extensive experience in biotherapeutics across a range of protein modalities
Proven track record engineering antibodies for clinical development
Deep knowledge of state-of-the-art protein engineering approaches
Experience with protein expression systems, purification methods, and characterization including developability assays
Prior experience liaising with CDMOs

Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
Understanding of high-throughput screening and bioanalytical technologies
Experience with generative AI models for protein and/or oligonucleotide design

Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.
$240,000-340,000
This role is eligible for:
Annual performance-based target bonus
Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

Annual performance-based target bonus
Comprehensive medical, dental, and vision coverage
Flexible paid time off and holidays
This reflects the typical offer range for this role, based on experience, role scope, and internal equity.
Perks including on-site gym, onsite lunch, and commuter support

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.

This listing is sourced directly from Manifold Bio's careers page and normalized into a canonical job model.