Isomorphic Labs
Head of Computational Drug Design, Cambridge, MA
Cambridge, MA
Sponsorship not specifiedDetected 28 days ago
PythonMachine LearningDeep LearningLLMsResearchLeadershipCollaborationAdaptability
About the role
- Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.
- A future enabled and enriched by the incredible power of machine learning.
- A future in which diseases are curtailed or cured starting with better and faster drug discovery.
Responsibilities
- Apply your knowledge and track record of modern drug design and discovery principles to deliver our Drug Design portfolio.
- Provide direct line management for a growing team of Computational Chemists. Set clear goals, provide regular feedback, support their professional development, and foster a collaborative and high-performance team environment.
- Collaborate both internally and with third party organisations, interacting within multidisciplinary teams, to support data-driven delivery of high quality scientific solutions to complex technical problems.
- Prepare detailed scientific proposals and reports to support new and ongoing programs.
- Prior experience of leading drug discovery programs, from hit finding to lead optimisation and candidate selection.
- Strong expertise in virtual screening, ligand and structure-based drug design using physics-based and ideally AI/ML methods.
- This role requires a unique blend of deep scientific expertise and the ability to lead both technical projects and high-performing teams, whilst contributing to or leading active drug discovery programs.
- You will provide scientific leadership and strategic direction for the Computational Drug Design team, responsible for delivery and guidance of projects to clinical candidate nomination.
- You will partner with our Head of Chemistry, Drug Design to champion the drug discovery pipeline, overseeing external collaborations (with CROs) and lead programs to deliver critical go/no-go milestones.
- Critical to this role will be the ability to build highly effective and efficient connectivity with Medicinal Chemistry, Biology and Pre-Clinical Development teams to accelerate pace to the clinic.
Nice to have
- Knowledge of modalities such as PROTACs, molecular glues, PPI inhibitors or ADCs.
- A track record of authorship of relevant scientific manuscripts.
- Culture and values
- It's not about finding people who think and act in the same way.
- These values help to guide our work and will continue to strengthen it.
- Thoughtful at Iso is about curiosity, creativity and care.
- It is about good people doing good, rigorous and future-making science every single day.
- Brave at Iso is about fearlessness, but it's also about initiative and integrity.
Benefits
- Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system.
- Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.
- We are building a dynamic team of Computational Chemists in Cambridge, MA within the Drug Design and Medical Research function.
- We foster a supportive, learning-focused environment where every member is valued, and continuous professional development is a priority.
Company info
- Embrace and champion our culture of inclusion and continuous professional development.
- As part of our expansion to Cambridge, MA, we are seeking an experienced and strategic Head of Computational Drug Design to join our foundational Drug Design team.
Visa & Work Authorization
- equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pre
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