Legend Biotech US
Scientist
Philadelphia, PA · Full-time
Sponsorship not specified$96k-$126kDetected 1 day ago
FlaskPCRqPCRCRISPRMolecular BiologyCell CultureResearchExperimental DesignCommunicationCollaborationProblem SolvingTime ManagementPublic SpeakingAdaptability
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About the role
- Legend Biotech seeks an experienced Scientist to join the Upstream team, Vector Biology in Philadelphia, with a focus on in-vivo CAR-T programs.
- development of lentiviral vector upstream processes, including seed train strategy and scale-up from small-scale to 40-Liter bioreactor runs.
Responsibilities
- Define and optimize the upstream process from shake flask through bioreactors, scaling to 40-L with reproducible performance and clear rational for operating parameters.
- Execute and optimize lentiviral vector production workflows supporting in-vivo CAR-T application, including transient transfection optimization and/or stable cell line optimization.
- Perform media optimization, feeding strategy development, and process control adjustments to improve yield, quality, scalability and robustness.
- Develop and execute fit-for-purpose studies to support scalability and readiness.
- Collaborate with internal teams within Vector Biology and coordinate cross-functional activities to support technology transfer to internal Technical Development team.
- Contribute technical input to cross-functional discussions on experimental design, comparability strategy, and progression of exploratory work into formal process development.
- Independently plan, perform, analyze, and interpret experiments with minimal supervision.
- Deliver clear data summaries and evidence-based recommendations to Vector Biology and cross-functional teams.
- Prepare high-quality technical reports, study summaries, and slide decks to support decisions on the upstream process development.
- Legend Biotech seeks an experienced Scientist to join the Upstream team, Vector Biology in Philadelphia, with a focus on in-vivo CAR-T programs. This independent contributor role will own hands-on execution and data-driven
Requirements
- MS degree with 4+ years
- or PhD degree with 1 year's prior industry experience in Bioengineering, Virology, Cell biology, Chemical Engineering, or related field.
- Hands-on experience in viral vector production, and characterization.
- Experience with mammalian suspension cell culture, transient transfection, and upstream bioprocess development.
- Experience supporting gene therapy platform development, preferably involving lentiviral vector applications.
- Excellent analytical and problem-solving skills with the ability to interpret data and recommend next steps.
- Proficiency in maintaining accurate experimental records and documenting data using electronic laboratory notebooks (ELNs) to ensure data traceability.
- Ability to work both independently and collaboratively in a multidisciplinary research environment.
Nice to have
- Experience scaling upstream processes from shake flasks to bioreactor system (up to 50 L preferred).
Skills
- Adhere to BSL-2 biosafety standards and Legend policies, maintaining accurate and compliant electronic lab notebooks and documentation.
- Ensure experimental reproducibility and data integrity through detailed and organized record-keeping.
Compensation
- $96,267 - $126,351 USD
- Pay Range (Base Pay):
Benefits
- Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one.
- These benefits are offered exclusively to permanent full-time employees.
- Contractors are not eligible for benefits through Legend Biotech.
Company info
- Legend Biotech is seeking a Scientist as part of the Research and Development team based in Philadelphia, PA.
- We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
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