Korro Bio

Principal Scientist, Analytical Sciences

60 First St, Cambridge, MA 02141 · Principal

Sponsorship not specified$160k-$190kDetected 43 days ago

GMPMass SpectrometryCommunication

About the role

By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.
Korro is based in Cambridge, Massachusetts.
They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work.

Serve as SME for synthetic oligonucleotide-based drug substance and drug product release and characterization assays. Develop and optimize analytical methods as needed.
Support analytical method validation, transfer, and troubleshooting to ensure compliance with cGMP standards.
Collaborate with the Process/Formulation Development teams to ensure seamless integration of analytical methods into DS and DP manufacturing workflows.
Support investigations and root cause analyses for any out-of-specification (OOS) results, deviations, or process failures.
Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform.
Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit.
This role will support and manage - the quality and stability of drug substances and drug products throughout the development lifecycle.
You will work closely with cross-functional teams and external partners to ensure that analytical data supports regulatory filings and clinical trial progression.

PhD in Analytical, Organic Chemistry, or related field with 3+ years' experience
or MS with 7+ years or BS with 10+ years of relevant industry experience.
3+ years of hands-on experience in analytical method development for small molecule therapeutics.
Experience in synthetic oligonucleotide therapeutics is desired.
Expertise in chromatographic (e.g., LC -UV, and LC-MS) and spectroscopic techniques (e.g., UV-Vis), with a strong understanding of method validation requirements.
Experience with compendial methods used to release sterile products and compendial method verification.
Familiarity with HRMS analysis in the identification of DS impurities.
Functioning knowledge of the chemical principles of molecular degradation pathways.
Strong understanding of cGMP and ICH guidelines for analytical aspects of small molecule sterile products in clinical development.
Experience with supporting design and management of stability studies

Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending acc

We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases.
Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

We are collaborative and united by a common mission.
Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization.

This listing is sourced directly from Korro Bio's careers page and normalized into a canonical job model.