Alpha9oncology
Senior Director, Clinical Dosimetry & Radiation Sciences
Boston, Massachusetts, USA · Director
Sponsorship not specifiedDetected 42 days ago
RecruitingClinical TrialsPharmacologyFDA RegulatoryCommunicationBiostatisticsRegulatory Affairs
About the role
- Company Summary Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors.
- Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue.
- More about Alpha-9 Oncology Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer.
Responsibilities
- Reporting into Clinical Development, this role serves as the internal scientific lead for dosimetry methodology and imaging quantification, ensuring rigor, consistency, and interpretability across multiple active studies.
- You will define and own how clinical dosimetry is performed at Alpha-9 and ensure it is fully integrated into trial design, dose escalation strategy, and regulatory decision-making.
- This role operates at the intersection of clinical development, clinical pharmacology, regulatory affairs, and external imaging partners, with direct influence on how quantitative radiopharmaceutical data is translated into clinical decisions.
- Lead clinical dosimetry strategy across Alpha-9's radiopharmaceutical programs, defining standards for absorbed dose calculation, time-activity modeling, and interpretation across early-phase clinical studies.
- Integrate dosimetry into clinical trial design and regulatory submissions, including protocols, amendments, investigator brochures, clinical study reports, and IND/CTA documentation.
- Partner closely with Clinical Development, Clinical Pharmacology, Biostatistics, and Clinical Operations to ensure dosimetry is embedded in dose selection strategy and study execution.
- Manage external imaging and dosimetry vendors and core laboratories, ensuring methodological consistency, data quality, and timely delivery across active programs.
- Support regulatory interactions and scientific communications, including responses to agencies, investigator meetings, abstracts, manuscripts, and conference presentations.
- Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.
Nice to have
- Establish and govern quantitative imaging standards for SPECT/CT and PET/CT, including acquisition protocols, reconstruction parameters, QC frameworks, and site qualification criteria.
- Serve as the internal authority on dosimetry, translating patient- and program-level dose data into actionable insights that inform dose escalation, safety evaluation, and clinical decision-making.
- Direct experience in radiopharmaceutical or radioligand therapy clinical programs required.
- Proven experience with quantitative SPECT/CT and PET/CT imaging workflows in clinical trial settings.
- Strong understanding of internal dosimetry principles (e.g., MIRD methodology) and organ/tumor absorbed dose modeling.
- Experience contributing to or supporting IND/CTA submissions and regulatory interactions involving imaging or dosimetry.
- Demonstrated ability to translate quantitative radiopharmaceutical data into clinical development decisions.
- Experience operating in cross-functional drug development teams, ideally across multiple concurrent clinical programs.
Benefits
- Alpha-9 Oncology is seeking a Medical Physicist to lead clinical dosimetry and quantitative imaging across our radiopharmaceutical clinical programs.
- PhD or MS in Medical Physics, Radiation Physics, Nuclear Medicine Physics, or related discipline (Ph.D. preferred).
- 6-10+ years of experience in radiopharmaceutical development, molecular imaging, or medical physics within oncology drug development.
- With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy.
Company info
- Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes.
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