Treeline Biosciences
Senior / Principal Scientist, Biochemistry
Watertown, Massachusetts, United States · Principal
Sponsorship not specified$158k-$184kDetected 2 days ago
Data AnalysisHRBioinformaticsProtein AnalysisLeadershipCommunicationCollaborationProblem SolvingMentoring
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PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70
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About the role
- We are seeking an experienced and enthusiastic biochemist to join our growing team.
Responsibilities
- Propose, design, and implement biochemical assays for compounds testing and mechanism-of-action studies.
- Lead from the bench to propose and develop new assays and drive hit identification, hit-to-lead, and lead optimization experiments in collaboration with a cross-functional project team.
- Design and conduct high-quality scientific experiments.
- Collaborate with chemistry, biology, lead discovery, and medicinal design teams to characterize and establish SAR, rapidly advancing the hit-to-lead process.
Requirements
- PhD in biochemistry or a related discipline with 5+ years of industry experience, or a comparable combination of postdoctoral training and industry experience.
- Experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
- Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaLISA, DSF.
- Experience with validating hits coming from DEL screening campaign
- Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on multidisciplinary teams.
Nice to have
- Knowledge of automation and experience with assay validation for HTS is beneficial.
- Experience using numerical simulations for experiment set up and data analysis
- Experience in working with challenging proteins.
- Working knowledge of adjacent disciplines (biophysics, structural biology, protein purification, biology, chemistry).
- General knowledge of signaling pathways, protein homeostasis, and regulation of gene expression beneficial.
- Track record of publications in high-impact scientific journals.
- This position is classified as exempt.
- Recruitment fraud statement
Skills
- Senior / Principal Scientist Biochemistry
- About Treeline
Compensation
- The anticipated annual base salary range for candidates who will work in Watertown is $158,000 to $184,000.
Company info
- About the Role We are seeking an experienced and enthusiastic biochemist to join our growing team.
- Keep the following in mind to protect yourself: - Treeline Biosciences will never ask for money from you as part of our recruitment process.
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This listing is sourced directly from Treeline Biosciences's careers page and normalized into a canonical job model.