Moderna

Moderna

Sr. Director, Head, Quantitative Systems Pharmacology

Cambridge, Massachusetts, USA · Director · Contract

No sponsorship$197k-$353kDetected 139 days ago
MATLABPharmacologyBioinformaticsCRISPRResearchExperimental DesignAnimal StudiesLeadershipCommunicationCollaborationMentoring

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odds of building a lasting career here

60Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role85
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

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Files H-1B transfers

1 transfer filing in the last year, covering 1 worker. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

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About the role

  • Moderna's Clinical and Quantitative Pharmacology (CQP) function is seeking an innovative, collaborative, and strategic leader to serve as Senior Director, Head of Quantitative Systems Pharmacology (QSP) capability.
  • In this role, you will provide strategic, scientific, and operational leadership for Moderna's mechanistic and systems pharmacology capabilities.
  • You will also represent Moderna as a thought leader in QSP and translational modeling.

Responsibilities

  • Develop and implement QSP strategy across priority therapeutic areas and modalities.
  • Partner with discovery, preclinical, clinical and platform teams to ensure quantitative and biological hypotheses guide experimental design and portfolio advancement.
  • Lead design, development, and application of mechanistic models (disease progression, target engagement, immune dynamics, biomarker relationships, etc.) to inform key program decisions.
  • Integrate multi-dimensional data and knowledge into multi-scale mechanistic models for translation and decision support.
  • Collaborate closely with Clinical Pharmacology, Translational Medicine, DMPK, research, bioinformatics, clinical development and platform sciences to design integrated quantitative strategies.
  • Embed QSP principles and deliverables into Moderna's R&D decision framework, including target validation, animal study design, human dose projection, and mechanism-of-action understanding.
  • Provide scientific and functional leadership for QSP activities across internal contributors, matrix partners, external vendors, and academic collaborators.
  • As needed, contribute to or lead cross-functional special projects, ad hoc initiatives, or new methodology pilots.
  • Proven track record of applying mechanistic and translational models to support drug development (preclinical through clinical).
  • Experience building infrastructure or toolchains for scalable modeling and data integration.

Requirements

  • Proficiency in modeling platforms such as MATLAB/SimBiology, Monolix, R, or Python.

Compensation

  • The salary range for this role is $196,700.00 - $353,400.00.

Benefits

  • Provide QSP input for INDs, IBs, regulatory filings, and Health Authority interactions.
  • Foster an inclusive, collaborative culture that promotes learning, creativity, and scientific excellence.
  • Experience contributing to regulatory filings and Health Authority interactions leveraging model-informed approaches.

Company info

  • By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture.

Visa & Work Authorization

  • thout regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexua
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This listing is sourced directly from Moderna's careers page and normalized into a canonical job model.