Genentech

Genentech

Principal Translational Scientist & Team Leader, Oncology Biomarkers & Translational Research

South San Francisco · Principal

Sponsorship not specified$142k-$263kDetected 5 hours ago
Machine LearningData ScienceStatisticsBioinformaticsMolecular BiologyResearchExperimental DesignLeadershipCommunicationPublic Speaking

About the role

  • Additionally, we conduct foundational clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches.
  • As a Principal Scientist, you will play a critical dual role: driving high-impact scientific strategy while leading and growing a dedicated team of translational research scientists.
  • This role offers a unique opportunity to leverage large-scale patient cohorts, clinical trial biospecimens, and emerging technologies to address previously intractable questions in cancer biology.

Responsibilities

  • Directly manage, mentor, and develop a high-performing team of translational research scientists, fostering a collaborative culture that bridges wet-lab biology and data science.
  • Co-design and oversee translational research strategies that address key biological and clinical questions across oncology programs.
  • Lead fit-for-purpose biomarker study design, including cohort selection, assay strategy, benchmarking, quality control, analytical workflows, and data interpretation.
  • Partner with biologists, laboratory scientists, computational biologists, statisticians, and AI/ML scientists to integrate data and translate findings into actionable hypotheses.

Requirements

  • Strong understanding of current and emerging tumor profiling technologies, including genomic, spatial, proteomic, liquid biopsy, single-cell, or multimodal approaches.
  • Demonstrated experience with translational study design, including assay selection, technical benchmarking, quality control, analytical workflows, and biological interpretation.
  • Ability to work effectively across multidisciplinary teams spanning biology, clinical development, laboratory sciences, computational biology, statistics, and AI/ML.
  • Deep expertise in at least one oncology therapeutic area, such as breast, lung, colorectal, prostate, or hematologic malignancies.

Nice to have

  • Experience supporting translational research within academic, clinical or commercial settings
  • Experience with statistical modeling, biomarker analysis, or multimodal data integration.
  • Experience evaluating or implementing novel profiling technologies in translational or clinical research.
  • Track record of publications, presentations, or contributions to biomarker development or precision oncology programs.
  • Experience navigating complex organizational matrix structures to secure resources and align executive stakeholders.
  • Genentech is an equal opportunity employer.
  • It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.

Compensation

  • The expected salary range for this position based on the primary location of California is $141,500 - $262,900 Annual.
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