Manifold Bio

Research Associate / Senior Research Associate, In Vitro Pharmacology

Boston · Senior

Sponsorship not specified$70k-$108kDetected 20 days ago

Full-Stack DevelopmentPharmacologyPCRqPCRFlow CytometryMolecular BiologyCell CultureResearchWestern BlottingAnimal Studies

About the role

Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
Position Manifold Bio is seeking a highly skilled and motivated Research Associate/ Senior Research Associate to join our in vitro pharmacology team.
You will execute essential molecular and biochemical assays for assessment and evaluation of oligonucleotide delivery shuttles and therapeutics.

Maintain a variety of cell lines, including immortalized cell lines, primary cells and iPSC-derived cells
Develop and execute program-specific assays for characterization/ testing of lead candidates and understanding MoA of shuttles and drug conjugates
Support the characterization of lead shuttles by conducting receptor internalization/ trafficking assays, on-cell binding assays and/or ligand competition assays
Support oligonucleotide programs through testing and qualification of reagents in disease program-specific cell types (e.g. qPCR primer/probe validation, antibody validation for western blots and ELISAs, siRNA sequence validation)
Maintain accurate and organized data entry and analysis
Collaborate with cross-functional teams in a dynamic research environment
Ability to optimize and troubleshoot molecular biology assays
Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match.
The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign.
In this role, you will support in vitro shuttled-oligonucleotide screening and disease programs through execution of essential assays that drive selection and Go/No Go decisions to progress molecules from screens into disease programs.

Experience culturing a variety of cell types, including immortalized cell lines, primary cells and/or iPSC-derived cells
Ability to follow SOPs and work independently in a high-throughput setting

Familiarity or experience with oligonucleotide screening
Flow cytometry and/or imaging experience
Bachelors or Masters degree and 1-2+ years of experience (biotech/pharma industry preferred)

Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.
$70,000-$108,000
This role is eligible for:
Annual performance-based target bonus
Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.
We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

Annual performance-based target bonus
Comprehensive medical, dental, and vision coverage
Flexible paid time off and holidays
This reflects the typical offer range for this role, based on experience, role scope, and internal equity.
Perks including on-site gym, onsite lunch, and commuter support

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.

This listing is sourced directly from Manifold Bio's careers page and normalized into a canonical job model.