Xaira Therapeutics

Associate Scientist, Immunogenicity Assessment

South San Francisco, California, United States

Sponsorship not specified$101k-$126kDetected 30 days ago

LLMsPharmacologyFDA RegulatoryExperimental DesignProtein AnalysisLeadershipCollaboration

About the role

You will operate at the interface of translational science and assay development, partnering closely with discovery biology, process development, and clinical teams to ensure immunogenic risk is identified and managed across the development pipeline.
The successful candidate is a hands-on immunogenicity scientist with a strong grasp of antibody biology, T and B cell immunology, and bioanalytical assay development.
You are comfortable evaluating variable factors in complex datasets, exercising scientific judgment to interpret relationships and solve problems within defined frameworks, and knowing when to seek guidance on broader implications.

Independently design and execute immunogenicity risk assessments including pre-existing ADA screening and T cell reactivity profiling.
Develop and optimize ADA assay platforms (liquid-phase bridging MSD ECL)
Design and execute T cell activation assays with fresh and cryopreserved PBMCs
Leverage AI tools to support experiment design, data summarization, and interpretation of complex immunogenicity datasets
Assist in preparing risk summaries and data packages for IND-enabling and clinical support.
Collaborate with discovery and process development teams to de-risk immunogenicity at candidate selection
share knowledge and support peers across functions.
Identify and implement improvements to immunogenicity workflows within personal scope
Maintain rigorous records and SOPs

Familiarity with bispecific antibody formats, novel scaffold biologics (VHH, minibinders), or T cell engager modalities and their unique immunogenicity risk profiles.
Proven track record of independent project ownership, cross-functional collaboration, and delivering scientific output in fast-paced discovery or development environments.
experience designing composite risk metrics, managing multi-donor PBMC datasets, and applying statistical methods to immunogenicity data.
Understanding of antigen presentation, T/B cell collaboration, and the molecular mechanisms driving ADA induction to endogenous proteins and biologic drugs.
Strong quantitative skills
Comfort using AI-assisted tools for scientific tasks including experiment design, literature synthesis, data summarization, and pattern recognition in complex immunogenicity datasets
openness to integrating emerging AI capabilities into day-to-day workflows.
Dedicated to inclusive scientific leadership and maintaining a collaborative, respectful team environment.

independently define cut points, validation strategies, and risk classification.
interpret MSD V-Plex cytokine readouts using appropriate metrics and recommend assay adjustments based on results.
apply AI-assisted approaches to identify patterns across multi-donor and multi-analyte studies and generate hypothesis-driven insights.
Align immunogenicity programs with EMA and FDA guidance
contribute to our risk assessment framework evolution and internal best practices.
BS or M.S. (6+ years industry experience) in Immunology, Biochemistry, Bioengineering, or a closely related field
industrial biopharmaceutical experience strongly preferred.
Proven expertise in ADA assay development and validation, including bridging immunoassay formats (MSD ECL, ELISA), with hands-on experience defining cut points, drug tolerance, and tiered confirmation strategies.

About Xaira Therapeutics
Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers.
We offer a competitive package that includes base salary, bonus, and equity.
The base pay range for this position is expected to be $101,000 - $126,000 annually
however, the base pay offered will vary depending on the market, job-related knowledge, skills and capabilities, and experience.
Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.
TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.

We are seeking a Scientist to join our Immunogenicity team within Biology & Pharmacology to lead and execute immunogenicity risk assessment for de novo protein therapeutics.

This listing is sourced directly from Xaira Therapeutics's careers page and normalized into a canonical job model.