Madrigal Pharmaceuticals
Senior Director, Agentic AI and Automation
PA - Conshohocken - Office, USA · Director · Full-time
Sponsorship not specified$256k-$312kDetected 27 days ago
PythonMATLABSQLDatabricksVector DatabasesAWSGCPAzureMachine LearningPyTorchData ScienceNLPLLMsRAGAgentic AIMLOpsComplianceOKRsCompensationSystems EngineeringHIPAAFDA RegulatoryResearchLeadership
About the role
- Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need.
- Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3).
- An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Responsibilities
- Partner with cross‑functional executives to prioritise high‑value automations across the business.
- Partner with executive stakeholders to prioritise high‑value automations (clinical, commercial, PV, manufacturing).
- Design secure agent‑to‑agent (A2A) communication with shared memory, credential vaults, RBAC.
- Implement enterprise MCP engine and Agent Protocol standards enabling human-agent-bot collaboration.
- Build event‑driven, low‑code pipelines (n8n, Dify, Glean) to trigger agentic RPA tasks in real time.
- Implement observability and governance (Arcade.dev, AgentOps, Langfuse).
- Lead a multi‑disciplinary squad of AI automation architects, prompt engineers, and product managers.
- Drive iterative product delivery using agile OKRs, rapid POCs, and continual KPI evaluation.
- Collaborate with open‑source communities, cloud partners, and leading vendors.
Requirements
- 15+ years leading AI/ML or intelligent‑automation initiatives
- 10+ years hands‑on with Python, SQL, R, MATLAB, PyTorch, Keras, Git.
- 8+ years implementing scalable AI/ML on platforms like Databricks or Dataiku, with strong AI/MLOps.
- Deep knowledge of cloud data platforms (AWS, Azure, GCP) and compliance (GxP, HIPAA, GDPR).
- Applies deep expertise in ML, generative AI, and systems engineering to solve complex, cross‑domain challenges.
- Typical Degree & Years of Experience
- 12+ years architecting ML/deep‑learning solutions incl. LLMs (GPT‑4, BERT, LLaMA, Dolly) and RAG pipelines.
- 8+ years building web apps (Dash, Streamlit, Shiny) and advanced data products.
- Strong theoretical foundation in ML/AI with contributions to papers and presentations.
- Exceptional written & verbal communication skills translating complex research to executives.
- Leadership/Autonomy
- Leads multi‑disciplinary squads and influences enterprise‑wide AI & automation strategy.
- Operates with significant autonomy to set technical direction and allocate resources.
- Problem Solving
Nice to have
- Advanced degree (Ph.D. preferred) in AI, Data Science, Computer Science, Applied Mathematics, Engineering, Physics, or related field.
- Ph.D. in a quantitative field plus 15+ years in AI/ML and intelligent automation.
Compensation
- Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity.
Benefits
- Strategic Leadership & Hyperautomation Vision
- 12+ years architecting ML/deep‑learning solutions incl.
Company info
- Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH.
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