Summit Therapeutics

Summit Therapeutics

Senior Principal Scientist

Palo Alto, CA (US) · Principal

Sponsorship not specified$168k-$197kDetected 7 days ago
RecruitingClinical TrialsFlow CytometryResearchExperimental DesignProtein AnalysisAnimal StudiesCommunicationCollaborationPublic Speaking

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odds of building a lasting career here

59Sponsors, lottery-bound
Cap-exempt (no lottery)0
Sponsors this role80
Entry-level history0
PERM / green-card track0
Lottery odds (Level IV)94
Fits your clock70

Sponsors, but it's cap-subject — you still face the weighted lottery (~61% per draw at Level IV). Good if you win; have a cap-exempt backup on your list.

Lottery odds assume a STEM candidate.

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Employer immigration record

from this employer's Department of Labor filings

Files H-1B transfers

4 transfer filings in the last year, covering 4 workers. Median labor-condition decision: 7 days. An employer that already files transfers is one that can take over an existing H-1B.

Sourced from Department of Labor LCA, PERM and prevailing-wage disclosure data. Employer matching is by name, so figures may be split across an employer's legal entities. Absence of a filing means none appears in our copy of the data, not that none exists.

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About the role

  • This is a hands-on, laboratory-based role in cell biology, focused on antibody screening and functional characterization in oncology and immunology.
  • The scientist takes primary responsibility for bench work, from binding assays through immune-effector and cell-killing assays, and contributes directly to the discovery, characterization, and advancement of new antibody pipeline candidates.

Responsibilities

  • Perform antibody ELISA (binding, specificity, and cross-reactivity) to screen and rank candidate antibodies.
  • Develop, optimize, and qualify assays, and analyze and summarize screening data to support candidate selection.
  • Design and execute ADCC, CDC, and ADCP assays to characterize the effector function of candidate antibodies.
  • Support animal studies, including PK/PD experiments, to connect in vitro activity with in vivo exposure and pharmacodynamic response.
  • Design and run experiments to characterize and advance candidate molecules.
  • Serve as a subject-matter expert in cross-functional teams and support decision-making.
  • Develop conference abstracts and presentations, and contribute manuscripts for peer-reviewed publication.
  • Perform other assigned responsibilities, including SOP and protocol drafting, instrument maintenance, etc.

Requirements

  • All employment businesses/agencies are required to contact Summit's Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.

Nice to have

  • Summit's core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people.
  • Summit's team is inspired to touch and help change lives through Summit's clinical studies in the field of oncology.
  • Summit has multiple global Phase 3 clinical studies, including:
  • Non-small Cell Lung Cancer (NSCLC)
  • Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
  • Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.
  • Colorectal Cancer (CRC)
  • Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Skills

  • Experience with multi-antibody characterization, including ELISA and cell-based binding assays for antibody screening.
  • Hands-on experience with ADCC, CDC, and ADCP assays for antibody characterization.
  • Preferred
  • Antibody affinity measurement (for example SPR or BLI) and reporter-gene assays for target binding or blockade.
  • Publication record in immuno-oncology.
  • Multiplex immunohistochemistry or fluorescence microscopy.
  • Experience in IND study reports.
  • This is the pay for this position
  • Pay Transparency
  • $168,000 - $197,000 USD
  • This may be different in other locations due to differences in the cost of labor.
  • The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Compensation

  • $168,000 - $197,000 USD
  • Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location.
  • The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Benefits

  • Experience, Education and Specialized Knowledge and

Company info

  • Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Equal opportunity

  • Summit Therapeutics Inc. is an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment.
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This listing is sourced directly from Summit Therapeutics's careers page and normalized into a canonical job model.