Arc Institute

Arc Institute

Scientist, Antibody Discovery, Horns Lab

Palo Alto, CA

Sponsorship not specified$121k-$160kDetected 138 days ago
PythonMachine LearningA/B TestingProject ManagementExcelBioinformaticsFlow CytometryMolecular BiologyCell CultureResearchProtein AnalysisCommunicationCollaborationTime ManagementMentoring

About the role

  • About Arc Institute The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases.
  • Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
  • While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress.

Responsibilities

  • Arc aims to provide first-class support-operationally, financially, and scientifically-that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.

Requirements

  • PhD in immunology, molecular biology, genomics, bioengineering, or a related field with 0-5 years of relevant post-PhD experience in either academia or industry.
  • Deep experience with single-cell sequencing technologies for immune profiling (e.g. 10X Genomics VDJ workflows).
  • Proficiency in flow cytometry, including multi-parameter panel design, optimization, and cell sorting.
  • Experience with antigen-binding characterization assays (e.g. ELISA, SPR, BLI).
  • Proven ability to analyze large and complex sequencing data sets using Python, R, or similar tools.
  • Experience with mammalian cell culture and standard molecular biology techniques (cloning, construct design).
  • Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a highly collaborative team player.

Nice to have

  • Experience with antigen-barcoded B cell sequencing approaches (e.g. LIBRA-seq, CITE-seq) is a plus.
  • Experience with antigen-specific cell sorting using labeled antigen probes (e.g. tetramer staining) is a plus.
  • Experience with human primary immune cell isolation and culture is a plus.
  • Experience with library design, pooled cloning, or high-throughput screening approaches is a plus.
  • Experience with protein biochemistry (expression, purification) is a plus.

Skills

  • Biomedical research has become increasingly dependent on complex tooling.
  • Scale the platform to multiplexed antigen libraries for immune repertoire profiling.
  • Apply these technologies to answer questions in human immunology.
  • Present key research findings at internal meetings and seminars, and external conferences.
  • Provide guidance and mentorship to Research Associates.

Compensation

  • The base salary range for this position is $121,250 to $159,500.

Company info

  • About Arc Institute
  • The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases.
  • Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models.
  • These include:
  • We believe that culture matters enormously in science and that excellence is difficult to sustain.
  • We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.
  • Arc has scaled to over 350 people to date.
  • With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly in the coming years.
  • About the position
  • We are seeking a highly skilled and motivated Scientist to join the Horns Lab at the Arc Institute.
  • In this position, you will lead the development of a novel platform for mapping human antibody specificities at scale.
  • You will play a critical role in building, optimizing, and applying a system for high-throughput identification of antigen-specific B cells and their antibody sequences through single-cell sequencing.
  • Your work will directly impact our understanding of human immunity and the discovery of new antibodies.
  • The successful candidate will develop and scale this antibody discovery platform within the Horns lab at the Arc Institute.
  • This work will initially focus on optimizing antigen-specific B cell isolation, establishing single-cell sequencing readouts, and scaling to multiplexed screens.
  • In the longer term, this platform will be applied to comprehensively profile human immune repertoires for understanding human immunology in health and disease.
  • The candidate will collaborate with other members of Arc's labs and Technology Centers in a dynamic environment to drive scientific discoveries, including groups within Arc Institute who are leaders in RNA biology, single-cell genomics, and AI/ML.
  • The ideal candidate would have a passion for cutting-edge technology development and a proven track record of working in an interdisciplinary environment and turning concepts into reliable methods and results.
  • This is an excellent opportunity for an ambitious self-starter who is motivated to apply his/her skills to diverse projects and enjoys working in a collaborative, fast-paced team environment.
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This listing is sourced directly from Arc Institute's careers page and normalized into a canonical job model.